Description

6-Bromo-2-(Trifluoromethyl)Quinolin-4-Amine is a high-value, multi-functional heterocyclic building block characterized by its bromine and trifluoromethyl substituents. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), offering unique reactivity and physicochemical properties. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, anti-cancer agents, and other biologically active molecules.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the quinoline scaffold and halogenated groups contribute to bioactivity and environmental stability.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters or charge-transport materials, due to its conjugated structure.
• Ligand and Catalyst Development: The amine and halogen functional groups make it a useful starting point for synthesizing novel ligands for metal catalysis in asymmetric synthesis.
• Fluorine Chemistry Studies: An important compound for research into the effects of the trifluoromethyl group on the reactivity and properties of heterocyclic systems.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira), enabling rapid diversification of the quinoline core.

Basic Information

Product Name	6-Bromo-2-(Trifluoromethyl)Quinolin-4-Amine
CAS No.	1700-91-0
Molecular Formula	C10H6BrF3N2
Molecular Weight	291.07 g/mol
Synonyms	4-Amino-6-bromo-2-(trifluoromethyl)quinoline; 6-Bromo-2-trifluoromethyl-4-quinolinamine; 6-Bromo-2-(trifluoromethyl)-4-quinolinamine; 4-Quinolinamine, 6-bromo-2-(trifluoromethyl)-; 2-(Trifluoromethyl)-6-bromoquinolin-4-amine; 6-Bromo-2-(trifluoromethyl)-4-aminoquinoline; 6-Bromo-2-trifluoromethylquinolin-4-ylamine
EINECS	Contact for details

Quality Control

Our 6-Bromo-2-(Trifluoromethyl)Quinolin-4-Amine is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled accordingly. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.