Description

n-Ethyl-2,2,2-trifluoroacetamide is a versatile fluorinated acetamide derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the unique reactivity imparted by the trifluoroacetyl group, enabling the introduction of fluorine atoms to enhance the metabolic stability and lipophilicity of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, particularly for developing novel active ingredients and specialty polymers.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), including protease inhibitors and other bioactive molecules.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and pesticides with improved environmental stability and efficacy.
• Material Science: Used in the production of fluorinated polymers and specialty materials that require enhanced chemical resistance and thermal stability.
• Organic Synthesis Reagent: Acts as a trifluoroacetylating agent in peptide chemistry and for protecting amine groups during complex multi-step syntheses.
• Liquid Crystal & Electronic Chemicals: Intermediate in the manufacturing of fluorinated liquid crystals and electronic chemicals for display and semiconductor applications.

Basic Information

Product Name	n-Ethyl-2,2,2-trifluoroacetamide
CAS No.	1682-66-2
Molecular Formula	C4H6F3NO
Molecular Weight	141.09 g/mol
Synonyms	N-Ethyltrifluoroacetamide; 2,2,2-Trifluoro-N-ethylacetamide; Ethyltrifluoroacetamide; TFAE; N-Ethyl-2,2,2-trifluoroacetamide; α,α,α-Trifluoro-N-ethylacetamide; Acetamide, 2,2,2-trifluoro-N-ethyl-; NSC 92466
EINECS	Contact for details

Quality Control

Our n-Ethyl-2,2,2-trifluoroacetamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for fine chemical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.