Description

n-(2,4-Dinitrophenyl)-L-Leucine is a specialized derivative of the essential amino acid L-leucine, modified with a 2,4-dinitrophenyl (DNP) group. This compound is primarily valued as a key intermediate in the synthesis of more complex molecules, particularly in pharmaceutical research and fine chemical manufacturing. It is essential for researchers and manufacturers in the fields of peptide chemistry, proteomics, and analytical biochemistry where it serves as a building block or a labeling reagent.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used in proteomics and enzyme studies as a derivatization agent for amino acid analysis and protein sequencing.
• Peptide Synthesis: Serves as a protected or modified leucine derivative in solid-phase and solution-phase peptide synthesis.
• Chromatography Standards: Acts as a high-purity reference standard for analytical method development and quality control in HPLC and LC-MS.
• Chemical Biology Probes: Utilized in the development of probes for studying protein function and interactions due to the distinctive properties of the DNP group.
• Fine Chemical Production: An intermediate in the multi-step synthesis of advanced organic compounds for various industrial applications.

Basic Information

Item	Detail
Product Name	n-(2,4-Dinitrophenyl)-L-Leucine
CAS No.	1655-57-8
Molecular Formula	C12H15N3O6
Molecular Weight	297.27 g/mol
Synonyms	L-Leucine, N-(2,4-dinitrophenyl)-; (S)-2-((2,4-Dinitrophenyl)amino)-4-methylpentanoic acid; DNP-L-Leucine; 2,4-Dinitrophenyl-L-leucine; N-2,4-DNP-L-leucine; Leucine, N-(2,4-dinitrophenyl)-, L-; 2,4-Dinitroaniline leucine derivative; (S)-4-Methyl-2-((2,4-dinitrophenyl)amino)pentanoic acid
EINECS	Contact for details

Quality Control

Our n-(2,4-Dinitrophenyl)-L-Leucine is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic methods for structural confirmation, to ensure it meets exacting standards for research and production. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, chiral purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.