Description

n-(2,4-Dinitrophenyl)-L-Proline is a specialized chiral derivative of the amino acid proline, featuring a 2,4-dinitrophenyl (DNP) protecting group. This compound is a valuable synthetic intermediate and analytical reagent, prized for its role in stereoselective synthesis and as a derivatization agent for chiral analysis. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced organic synthesis, peptide chemistry, and the development of analytical methods for enantiomeric purity determination.

Application

• Chiral Derivatizing Agent: Used in high-performance liquid chromatography (HPLC) and other analytical techniques to separate and quantify enantiomers of amino acids and amines.
• Peptide Synthesis Intermediate: Serves as a protected proline derivative in the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Asymmetric Synthesis Building Block: Employed as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Biochemical Research: Used in studies of enzyme inhibition, receptor-ligand interactions, and the structure-activity relationships of proline-containing compounds.
• Pharmaceutical Development: Acts as a key intermediate in the research and development stages of new active pharmaceutical ingredients (APIs), particularly those targeting neurological and cardiovascular diseases.
• Reference Standard: Supplied as a high-purity analytical standard for method development and quality control in analytical laboratories.

Basic Information

Product Name	n-(2,4-Dinitrophenyl)-L-Proline
CAS No.	1655-55-6
Molecular Formula	C₁₁H₁₁N₃O₆
Molecular Weight	281.22 g/mol
Synonyms	L-Proline, N-(2,4-dinitrophenyl)-; (S)-1-(2,4-Dinitrophenyl)pyrrolidine-2-carboxylic acid; N-DNP-L-Proline; DNP-L-Proline; 2,4-Dinitrophenyl-L-proline; 2-Pyrrolidinecarboxylic acid, 1-(2,4-dinitrophenyl)-, (S)-; L-Proline, N-2,4-dinitrophenyl derivative
EINECS	Contact for details

Quality Control

Our n-(2,4-Dinitrophenyl)-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity verification, and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.