Description

4-Bromo-3-(trifluoromethyl)benzoic acid is a high-purity aromatic carboxylic acid derivative, distinguished by its bromine and trifluoromethyl substituents which confer unique reactivity and physicochemical properties. This compound serves as a critical advanced pharmaceutical intermediate and versatile building block for the synthesis of complex organic molecules. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science industries seeking to introduce specific halogenated and fluorinated motifs into their target structures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting neurological disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and pesticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Sonogashira couplings for carbon-carbon bond formation.
• Ligand & Catalyst Development: Utilized in the preparation of specialized ligands for metal catalysis and organocatalysts.
• Polymer Modification: Incorporated into polymer backbones to alter thermal stability, solubility, and other material properties.
• Chemical Research & Development: A valuable reagent for academic and industrial research exploring new synthetic methodologies and fluorine chemistry.

Basic Information

Product Name	4-Bromo-3-(trifluoromethyl)benzoic Acid
CAS No.	1622-14-6
Molecular Formula	C8H4BrF3O2
Molecular Weight	269.02 g/mol
Synonyms	4-Bromo-3-(trifluoromethyl)benzoic acid; 3-Trifluoromethyl-4-bromobenzoic acid; Benzoic acid, 4-bromo-3-(trifluoromethyl)-; 4-Bromo-alpha,alpha,α-trifluoro-m-toluic acid; 2-Bromo-5-carboxybenzotrifluoride; 4-Bromo-3-trifluoromethylbenzoic acid; 4-Bromo-3-trifluoromethyl-benzoic acid; 4-Bromo-3-(trifluoromethyl)benzenecarboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-(trifluoromethyl)benzoic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and consistent batch-to-batch performance. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles. Our production adheres to cGMP standards where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.