Description

14-Hydroxy-3-Methoxy-6-Oxo-Morphinan 6-Ethylene Ketal is a key pharmaceutical intermediate and a protected derivative of morphinan alkaloids. This compound is critical for ensuring the stability and reactivity of the core structure during complex synthetic sequences, particularly in the development of active pharmaceutical ingredients (APIs). It is primarily required by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for the synthesis of specialized therapeutics.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of opioid analgesics and related central nervous system (CNS) active compounds.
• Organic Synthesis Research: Used in academic and industrial R&D for studying morphinan chemistry and developing novel synthetic pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry: Employed in scale-up and process optimization for the commercial manufacturing of advanced APIs.
• Medicinal Chemistry: Utilized in structure-activity relationship (SAR) studies to explore new therapeutic candidates within the morphinan class.

Basic Information

Product Name	14-Hydroxy-3-Methoxy-6-Oxo-Morphinan 6-Ethylene Ketal
CAS No.	1612-45-9
Molecular Formula	C20H25NO5
Molecular Weight	359.42 g/mol
Synonyms	6,14-Etheno-7,8-dihydromorphine 6-ethylene ketal; 14-Hydroxy-3-methoxy-6-oxomorphinan 6-ethylene ketal; 6,14-Ethenomorphinan-7,8-diol, 6-ethylene ketal, 3-methoxy-; 6,14-Etheno-7,8-dihydronormorphine 6-ethylene ketal derivative; 6-Ethylene ketal of 14-hydroxy-3-methoxy-6-oxomorphinan; Morphinan-6-one, 14-hydroxy-3-methoxy-, 6-ethylene ketal
EINECS	Contact for details

Quality Control

Our 14-Hydroxy-3-Methoxy-6-Oxo-Morphinan 6-Ethylene Ketal is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.