Description

Trimethylacetic Anhydride is a versatile and highly reactive acylating agent, also known as pivalic anhydride. Its primary commercial value lies in its role as a key reagent for introducing the bulky, sterically hindered pivaloyl (trimethylacetyl) group, which is crucial for enhancing the stability and bioavailability of target molecules. This compound is essential for manufacturers in the pharmaceutical, agrochemical, and specialty polymer industries, where it is used in the synthesis of active ingredients, prodrugs, and advanced materials. The product is supplied under the identifier CAS NO 1538-75-6.

Application

• Pharmaceutical Intermediates: Key reagent for the synthesis of prodrugs and active pharmaceutical ingredients (APIs), particularly for creating pivalate ester derivatives that improve metabolic stability.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators where the pivaloyl group modifies activity and environmental persistence.
• Polymer Chemistry: Acts as a modifying agent or cross-linking component in the production of specialty polymers, resins, and coatings.
• Perfumery and Fragrance: Employed in the acylation of alcohols to produce specific ester compounds used in fragrance formulations.
• Organic Synthesis: A fundamental acylating agent in laboratories and pilot plants for protecting groups and introducing tertiary acid structures in complex molecule construction.
• Dye and Pigment Manufacturing: Utilized in the synthesis of certain dye intermediates where the bulky group affects color properties and solubility.

Basic Information

Product Name	Trimethylacetic Anhydride
CAS No.	1538-75-6
Molecular Formula	C10H18O3
Molecular Weight	186.25 g/mol
Synonyms	Pivalic Anhydride; 2,2-Dimethylpropanoic Anhydride; Trimethylacetyl Anhydride; Pivaloyl Oxide; Neopentanoic Anhydride; 2,2-Dimethylpropionic Anhydride; tert-Butylcarboxylic Anhydride
EINECS	216-257-8

Quality Control

Our Trimethylacetic Anhydride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, identity, and impurity profiles. We adhere to relevant industry standards and can provide material suitable for various application grades upon request, ensuring reliable supply and technical support for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent hydrolysis. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Pivalic Acid	≤ 1.5%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.408 - 1.412
Density (g/mL at 20°C)	0.915 - 0.925

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.