Description

L-n-Trifluoroacetylglutamic Anhydride is a specialized fluorinated anhydride derivative of glutamic acid, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in enabling the efficient introduction of a protected glutamic acid moiety with enhanced reactivity and lipophilicity due to the trifluoroacetyl group. This compound is essential for research and development laboratories in the pharmaceutical and agrochemical sectors, particularly for the synthesis of peptide mimetics, prodrugs, and novel bioactive molecules where precise stereochemistry and fluorine incorporation are required.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of peptide-based drugs, enzyme inhibitors, and targeted therapeutics.
• Prodrug Synthesis: Used in the design and synthesis of prodrugs to improve drug bioavailability and stability.
• Agrochemical Research: Building block for developing novel pesticides and herbicides with fluorinated active ingredients.
• Peptide Mimetics: Facilitates the creation of non-peptidic compounds that mimic peptide structure and function.
• Bioconjugation Chemistry: Employed in linking molecules to peptides or proteins for diagnostic and therapeutic applications.
• Academic & R&D: A valuable reagent in organic chemistry research for studying reaction mechanisms and developing new synthetic methodologies.

Basic Information

Product Name	L-n-Trifluoroacetylglutamic Anhydride
CAS No.	1535-57-5
Molecular Formula	C7H6F3NO4
Molecular Weight	225.12 g/mol
Synonyms	L-N-(Trifluoroacetyl)glutamic Anhydride; (S)-2-(2,2,2-Trifluoroacetamido)pentanedioic Anhydride; N-Trifluoroacetyl-L-glutamic Anhydride; N-TFA-L-glutamic Anhydride; L-Glutamic Acid, N-(Trifluoroacetyl)-, Anhydride; (4S)-4-[(2,2,2-Trifluoroacetyl)amino]-5-oxo-4,5-dihydrofuran-2-carboxylic Acid; 1535-57-5; N-[(1S)-1,5-Dihydro-1,5-dioxo-4-furanyl]-2,2,2-trifluoroacetamide
EINECS	Contact for details

Quality Control

Our L-n-Trifluoroacetylglutamic Anhydride is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding synthetic applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in common organic solvents (DMF, DMSO, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.