Description

Morpholinophosphoramidic Dichloride is a highly reactive organophosphorus compound primarily used as a key phosphorylating and coupling agent in organic synthesis. Its value lies in its ability to efficiently introduce the morpholino phosphoramidate moiety, a crucial intermediate in the production of complex molecules. This chemical is essential for research and manufacturing in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for the synthesis of nucleotide analogs, phosphoramidate prodrugs, and advanced ligands.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of antiviral and anticancer nucleotide prodrugs (e.g., ProTide technology).
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides that contain phosphoramidate functional groups.
• Peptide & Oligonucleotide Chemistry: Serves as a phosphorylating agent in solid-phase synthesis for modifying peptides and creating oligonucleotide analogs.
• Ligand and Catalyst Preparation: Employed to synthesize phosphorus-containing ligands for metal catalysis and coordination chemistry.
• Chemical Research: A versatile reagent for academic and industrial R&D in organophosphorus chemistry and medicinal chemistry.
• Polymer Modification: Used to introduce phosphoramidate groups into polymers for specialty material applications.

Basic Information

Product Name	Morpholinophosphoramidic Dichloride
CAS No.	1498-57-3
Molecular Formula	C4H9Cl2N2O2P
Molecular Weight	213.00 g/mol
Synonyms	Morpholine Phosphorodiamidic Dichloride; N,N-Dichlorophosphoromorpholidate; Morpholino Phosphorodichloridate; Phosphorodichloridic Acid Morpholide; 2,2,2-Trichloroethyl Phosphoromorpholidate (precursor related); Morpholine, 4-(dichlorophosphinyl)-; NSC 403014; Phosphorochloridic acid, morpholide
EINECS	Contact for details

Quality Control

Our Morpholinophosphoramidic Dichloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.