Description

2-Cyclobutyl-2-Hydroxy-2-Phenylacetic Acid is a specialized chiral α-hydroxy acid derivative of significant interest in advanced organic synthesis. This compound matters as a versatile building block for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for applications in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel therapeutic agents, including potential CNS-active drugs and enzyme inhibitors.
• Asymmetric Synthesis: Utilized as a precursor or auxiliary in stereoselective reactions to introduce the cyclobutyl-phenyl moiety into target molecules.
• Agrochemical Research: Serves as a building block for developing new crop protection agents and herbicides with specific activity profiles.
• Ligand and Catalyst Development: Used in the design and synthesis of novel chiral ligands for metal-catalyzed reactions.
• Fine Chemical Production: Employed in the custom synthesis of high-value, complex organic compounds for various industrial applications.
• Academic & R&D: A valuable compound for methodological studies in organic chemistry and for exploring new reaction pathways.

Basic Information

Product Name	2-Cyclobutyl-2-Hydroxy-2-Phenylacetic Acid
CAS No.	1460-47-5
Molecular Formula	C₁₂H₁₄O₃
Molecular Weight	206.24 g/mol
Synonyms	α-Cyclobutylmandelic Acid; 2-Hydroxy-2-cyclobutyl-2-phenylacetic Acid; Cyclobutyl(phenyl)glycolic Acid; (RS)-2-Cyclobutyl-2-hydroxy-2-phenylacetic Acid; (±)-2-Cyclobutylmandelic Acid; DL-2-Cyclobutyl-2-hydroxy-2-phenylacetic Acid; Phenyl(cyclobutyl)glycolic Acid; Mandelic acid, 2-cyclobutyl-
EINECS	Contact for details

Quality Control

Our 2-Cyclobutyl-2-Hydroxy-2-Phenylacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed results from techniques such as HPLC, NMR, and IR spectroscopy. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids. For long-term storage, consider an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.