Description

2'-Hydroxy-5'-Nitroacetophenone is a versatile aromatic ketone derivative, serving as a crucial synthetic intermediate in advanced organic chemistry. Its value lies in the strategic positioning of its functional groups, which enable selective reactions for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity building blocks for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing nitro- and hydroxy-substituted aromatic systems.
• Agrochemical Synthesis: Used in the development of herbicides, pesticides, and plant growth regulators, leveraging its reactive nitro and carbonyl groups.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing heterocyclic compounds, dyes, and complex organic molecules via condensation, reduction, or cyclization reactions.
• Chemical Research: Serves as a standard or starting material in methodological studies for novel organic transformations and catalysis research.
• Material Science Precursor: Potential use in the synthesis of organic ligands for metal-organic frameworks (MOFs) or functional polymers.

Basic Information

Product Name	2'-Hydroxy-5'-Nitroacetophenone
CAS No.	1450-76-6
Molecular Formula	C8H7NO4
Molecular Weight	181.15 g/mol
Synonyms	1-(2-Hydroxy-5-nitrophenyl)ethanone; 2-Acetyl-4-nitrophenol; 5-Nitro-2-hydroxyacetophenone; 2-Hydroxy-5-nitroacetophenone; 2-Acetyl-4-nitrophenol; 1-(2-Hydroxy-5-nitrophenyl)ethan-1-one; 5-Nitro-2'-hydroxyacetophenone; NSC 403697
EINECS	Contact for details

Quality Control

Our 2'-Hydroxy-5'-Nitroacetophenone is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all critical quality parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its aromatic nitro and ketone functionalities, it should be stored separately from strong oxidizing agents, strong bases, and reducing agents.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	148°C - 152°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.