Description

Benzanthracene-5,6-Dihydrodiol is a high-purity dihydrodiol derivative of benz[a]anthracene, a key polycyclic aromatic hydrocarbon (PAH) metabolite. This compound is of significant value in biochemical and toxicological research for studying metabolic activation pathways and DNA adduct formation. It serves as a critical reference standard and synthetic intermediate for researchers in pharmaceutical development, environmental toxicology, and cancer research.

Application

• Biochemical Research Standard: Used as a certified reference material (CRM) for the quantification and identification of PAH metabolites in complex biological matrices.
• Toxicology Studies: Essential for investigating the metabolic activation of benz[a]anthracene and its role in carcinogenesis, particularly in in vitro and in vivo model systems.
• Metabolite Synthesis: Acts as a key synthetic precursor for the preparation of further metabolites, such as diol-epoxides, which are the ultimate carcinogenic forms of PAHs.
• Environmental Analysis: Employed in method development and calibration for analytical techniques (e.g., HPLC-MS, GC-MS) monitoring PAH exposure and bioactivation.
• DNA Adduct Research: Used in studies to understand and characterize the covalent binding of activated PAH metabolites to DNA, a critical step in mutagenesis.

Basic Information

Product Name	Benzanthracene-5,6-Dihydrodiol
CAS No.	1421-78-9
Molecular Formula	C₁₈H₁₄O₂
Molecular Weight	262.30 g/mol
Synonyms	Benz[a]anthracene-5,6-dihydrodiol; 5,6-Dihydro-5,6-dihydroxybenz[a]anthracene; Benz(a)anthracene 5,6-diol; BA-5,6-diol; 5,6-Dihydroxy-5,6-dihydrobenz[a]anthracene; trans-Benz[a]anthracene-5,6-dihydrodiol; (±)-Benz[a]anthracene-5,6-dihydrodiol
EINECS	Contact for details

Quality Control

Our Benzanthracene-5,6-Dihydrodiol is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques, including HPLC and NMR, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, chromatographic data, and spectroscopic confirmation is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.