Description

(17R)-4',5'-Dihydrospiro[Estr-4-Ene-17,2'(3'H)-Furan]-3-One is a high-purity, synthetic steroid derivative with a complex spirocyclic structure. This compound serves as a critical advanced pharmaceutical intermediate and a valuable scaffold in organic synthesis for developing novel bioactive molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of steroidal drugs and high-value chemical entities.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel steroidal active pharmaceutical ingredients (APIs) and hormone analogs.
• Research & Development: Used as a reference standard and a starting material in medicinal chemistry for structure-activity relationship (SAR) studies.
• Organic Synthesis: Valuable spirocyclic precursor for constructing complex molecular architectures in academic and industrial laboratories.
• Biochemical Research: Potential tool compound for studying steroid receptor interactions and metabolic pathways.

Basic Information

Product Name	(17R)-4',5'-Dihydrospiro[Estr-4-Ene-17,2'(3'H)-Furan]-3-One
CAS No.	1235-13-8
Molecular Formula	C20H26O2
Molecular Weight	298.42 g/mol
Synonyms	4',5'-Dihydrospiro[est-4-ene-17,2'(3'H)-furan]-3-one; (17R)-Spiro[estra-4,9-diene-17,2'-oxolane]-3-one; 17β-Spiro[estra-4,9-diene-17,2'-oxolane]-3-one; 3-Oxo-17R-spiro[estra-4,9-diene-17,2'-(3'H)-furan]; Spiro[estra-4,9-diene-17,2'-oxolane]-3-one; 17R-Spirofuran-3-one steroid derivative; Estra-4,9-diene-17-spiro-2'-oxolane-3-one
EINECS	Contact for details

Quality Control

Our (17R)-4',5'-Dihydrospiro[Estr-4-Ene-17,2'(3'H)-Furan]-3-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC purity analysis and spectroscopic identification (IR, NMR), to ensure it meets exacting specifications for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound should be handled in a well-ventilated area, and prolonged exposure to air should be minimized to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.