Description

3' 4'-Dichlorobenzamil CAS NO 1166-01-4 is a potent and selective inhibitor of the sodium-calcium exchanger (NCX), a key membrane transport protein. This compound is a critical research tool for studying calcium homeostasis, ion channel function, and related cellular signaling pathways in cardiovascular and neurological systems. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on ion channel pharmacology and drug discovery.

Application

• Pharmacological Research: As a standard reference compound for studying the sodium-calcium exchanger (NCX) in cellular and tissue models.
• Cardiovascular Research: Investigation of myocardial ischemia-reperfusion injury, cardiac hypertrophy, and arrhythmia mechanisms.
• Neuroscience Research: Exploration of calcium dysregulation in neuronal excitotoxicity, stroke models, and neurodegenerative diseases.
• Biochemical Assay Development: Used in high-throughput screening (HTS) campaigns to identify novel NCX modulators.
• Signal Transduction Studies: Tool for dissecting calcium-dependent signaling cascades and their physiological roles.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.

Basic Information

Product Name	3' 4'-Dichlorobenzamil
CAS No.	1166-01-4
Molecular Formula	C24H20Cl2N2O3
Molecular Weight	455.34 g/mol
Synonyms	3',4'-Dichlorobenzamil; Benzamil, 3',4'-dichloro-; 3,4-Dichlorobenzamil; NCX Inhibitor; Sodium-Calcium Exchanger Inhibitor; 2-[[(3,4-Dichlorophenyl)methyl]amino]-N-[2-[(2,3,4-trimethoxyphenyl)methylamino]ethyl]-5-pyridinecarboxamide; (3,4-Dichlorobenzyl){2-[(2,3,4-trimethoxybenzyl)amino]ethyl}carbamoylpyridin-2-ium
EINECS	Contact for details

Quality Control

Our 3' 4'-Dichlorobenzamil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C. Keep container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.