Description

n-Cbz-L-Glutamic Acid is a protected derivative of the amino acid L-glutamic acid, where the α-amino group is safeguarded by a carboxybenzyl (Cbz) group. This compound is a crucial chiral building block and intermediate in the synthesis of peptides, pharmaceuticals, and fine chemicals, offering precise control over stereochemistry. It is primarily utilized by research institutions, pharmaceutical development labs, and manufacturers in the life sciences sector for constructing complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of peptide-based drugs, enzyme inhibitors, and other active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Serves as a protected glutamic acid residue in solid-phase and solution-phase peptide synthesis, enabling the construction of specific peptide sequences.
• Biochemical Research: Used as a substrate or precursor in enzymatic studies, metabolic pathway research, and the development of biochemical probes.
• Fine Chemical Production: An important intermediate for manufacturing specialty chemicals, including complex ligands, catalysts, and advanced materials.
• Academic & R&D: Employed in university and corporate laboratories for synthetic organic chemistry projects and the development of new synthetic methodologies.

Basic Information

Product Name	n-Cbz-L-Glutamic Acid
CAS No.	1155-62-0
Molecular Formula	C₁₃H₁₅NO₆
Molecular Weight	281.26 g/mol
Synonyms	N-Carbobenzoxy-L-glutamic Acid; Nα-Cbz-L-glutamic Acid; (S)-2-(((Benzyloxy)carbonyl)amino)pentanedioic Acid; Z-L-Glutamic Acid; L-Glutamic Acid, N-carboxy-, anhydride with benzyl alcohol; CBZ-L-Glutamic Acid; NSC 3349; Benzyl N-[(S)-1,3-dicarboxypropyl]carbamate
EINECS	214-560-7

Quality Control

Our n-Cbz-L-Glutamic Acid is produced and tested under a strict quality management system. Each batch is analyzed to ensure high chemical purity, correct stereochemistry, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and other critical parameters. Our quality commitment supports applications requiring reliable and traceable raw materials for research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.