Description

n-Carbobenzyloxy-L-Alanine (CAS NO 1142-20-7) is a vital protected amino acid derivative widely used as a key building block in peptide synthesis. Its primary value lies in providing a versatile and stable intermediate for constructing complex peptides and active pharmaceutical ingredients (APIs). This compound is essential for research institutions, pharmaceutical manufacturers, and fine chemical producers engaged in the development of peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental reagent for the sequential assembly of peptides on resin supports.
• Solution-Phase Peptide Synthesis: Used in classical coupling reactions to introduce the L-alanine moiety with orthogonal protection.
• Pharmaceutical Intermediate: Serves as a critical precursor in the manufacture of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in academic and industrial R&D for studying peptide structure, function, and for creating custom peptide sequences.
• Protecting Group Strategy: The carbobenzyloxy (Cbz) group provides temporary N-terminal protection that can be selectively removed under mild hydrogenolytic conditions.
• Combinatorial Chemistry: Used in libraries for drug discovery to generate diverse arrays of peptide-like molecules.

Basic Information

Product Name	n-Carbobenzyloxy-L-Alanine
CAS No.	1142-20-7
Molecular Formula	C11H13NO4
Molecular Weight	223.23 g/mol
Synonyms	N-Cbz-L-Alanine; N-Carbobenzyloxy-L-alanine; (S)-2-(((Benzyloxy)carbonyl)amino)propanoic acid; Cbz-L-Ala-OH; Cbz-L-Alanine; Z-L-Alanine; Z-Ala-OH; L-Alanine, N-[(phenylmethoxy)carbonyl]-
EINECS	214-537-8

Quality Control

Our n-Carbobenzyloxy-L-Alanine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, chiral purity, and identification via spectroscopic methods. A Certificate of Analysis (COA) detailing all relevant specifications is available for every batch upon request, supporting compliance in regulated applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Melting Point	84 - 88 °C
Specific Rotation	-12.0° to -15.0° (c=1 in DMF)
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.