Description

n-Acetyl-L-Leucine Ethyl Ester is a protected derivative of the essential amino acid L-Leucine, widely utilized as a key chiral building block in organic synthesis. This compound is valued for its role in introducing the lipophilic leucine side chain while protecting the amine functionality, enabling precise peptide and pharmaceutical intermediate construction. It is primarily sought by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) and peptide-based therapeutics.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate the L-leucine residue with a protected N-terminus.
• Biochemical Research: Serves as a substrate or precursor in enzymatic studies and metabolic pathway investigations.
• Fine Chemical Production: Employed in the manufacture of complex organic molecules, flavors, and fragrances requiring high stereochemical purity.
• Protecting Group Strategy: The acetyl group protects the amine during multi-step synthetic sequences, which can be selectively removed later.

Basic Information

Product Name	n-Acetyl-L-Leucine Ethyl Ester
CAS No.	1114-55-2
Molecular Formula	C10H19NO3
Molecular Weight	201.26 g/mol
Synonyms	L-Leucine, N-acetyl-, ethyl ester; Ethyl N-acetyl-L-leucinate; Ac-Leu-OEt; N-Acetyl-L-leucine ethyl ester; N-Acetylleucine ethyl ester; (S)-2-(Acetylamino)-4-methylpentanoic acid ethyl ester; Ethyl (2S)-2-acetamido-4-methylpentanoate; NSC 3349
EINECS	214-215-6

Quality Control

Our n-Acetyl-L-Leucine Ethyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical and research applications. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]20/D	-20.0° to -24.0° (c=1 in ethanol)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.