Description

Sodium Bis(Trimethylsilyl)Amide (CAS NO 1070-89-9) is a highly versatile and powerful non-nucleophilic base, essential for deprotonation reactions in sensitive organic syntheses. Its value lies in its ability to generate reactive anions under mild conditions, particularly for substrates incompatible with stronger inorganic bases. This reagent is a critical component for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, enabling the production of complex molecules with high precision and yield.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the generation of enolates and other carbanions in the synthesis of active pharmaceutical ingredients (APIs).
• Polymer & Material Science: Used as an initiator or catalyst in the production of specialty silicones and advanced polymeric materials.
• Agrochemical Manufacturing: Facilitates condensation and cyclization reactions in the production of complex herbicide and pesticide molecules.
• Fine Chemical Production: Employed in the synthesis of flavors, fragrances, and other high-value specialty chemicals requiring stringent reaction control.
• Lithium-Ion Battery Electrolytes: Acts as a crucial additive and purification agent in the formulation of high-performance electrolyte solutions.
• Academic & R&D Laboratories: A staple reagent for methodological development and exploratory synthesis in organometallic and organic chemistry.

Basic Information

Product Name	Sodium Bis(Trimethylsilyl)Amide
CAS No.	1070-89-9
Molecular Formula	C6H18NNaSi2
Molecular Weight	183.37 g/mol
Synonyms	Sodium Hexamethyldisilazide; NaHMDS; Sodium HMDS; 1,1,1-Trimethyl-N-(trimethylsilyl)silanaminato Sodium; Sodium Bis(trimethylsilyl)azanide; Sodium (Trimethylsilyl)amide; Sodium Tris(trimethylsilyl)amide (common misnomer)
EINECS	213-978-2

Quality Control

Our Sodium Bis(Trimethylsilyl)Amide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including assay by titration and impurity profiling, to ensure it meets the high-purity standards required for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and safety parameters is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly hygroscopic and moisture-sensitive nature, this product must be stored under a dry, inert atmosphere (argon or nitrogen). Recommended storage temperature is 2-8°C. The container should be kept in a cool, dry, well-ventilated place, away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms
Assay (Titration)	≥ 95.0%
Solubility (Test in Toluene/Hexane)	Clear, colorless solution

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.