Description

2-Keto-3-Deoxyoctonate (KDO) is a critical monosaccharide component of bacterial lipopolysaccharides (LPS) and a key intermediate in the biosynthesis of the outer membrane of Gram-negative bacteria. Its precise structure makes it an essential building block for research into bacterial pathogenesis, vaccine development, and novel antibiotic targets. This high-purity compound is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science research sectors.

Application

• Biochemical Research: As a fundamental substrate for studying the enzymes of the KDO biosynthesis pathway, such as KDO-8-phosphate synthase and CMP-KDO synthetase.
• Glycobiology & Glycochemistry: Serving as a crucial precursor for the chemical and enzymatic synthesis of complex bacterial oligosaccharides and glycoconjugates.
• Vaccine Development: Used in the research and development of conjugate vaccines targeting pathogenic Gram-negative bacteria, where KDO is a potential antigenic determinant.
• Antimicrobial Discovery: A key molecule for screening and developing novel inhibitors that target the unique bacterial metabolic pathways involving KDO, offering potential for new antibiotics.
• Enzyme Assay Substrate: Employed as a specific substrate in activity assays for enzymes involved in LPS biosynthesis.
• Analytical Standard: Used as a high-purity reference standard in HPLC, LC-MS, and NMR for the identification and quantification of bacterial sugars in complex matrices.

Basic Information

Item	Details
Product Name	2-Keto-3-Deoxyoctonate
CAS No.	1069-03-0
Molecular Formula	C8H13O7- (typically as a salt, e.g., ammonium or sodium)
Molecular Weight	221.18 g/mol (Free acid)
Synonyms	3-Deoxy-D-manno-oct-2-ulosonic acid; KDO; 2-Keto-3-deoxyoctonic acid; 3-Deoxy-D-manno-octulosonic acid; 3-Deoxy-D-manno-2-octulosonic acid; D-3-Deoxy-manno-octulosonic acid; 2-Keto-3-deoxy-D-manno-octonate; 2-Keto-3-deoxyoctulosonate
EINECS	213-947-8

Quality Control

Our 2-Keto-3-Deoxyoctonate is produced under stringent conditions to ensure the high purity and consistency required for advanced research applications. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and optical rotation analysis, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We adhere to a quality management system to guarantee traceability and reliability for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.