Description

Diethyl (2-Oxopropyl)Phosphonate is a versatile organophosphorus compound, specifically a phosphonate ester, that serves as a critical building block in organic synthesis. Its primary value lies in its role as a key reagent in the Horner-Wadsworth-Emmons (HWE) olefination reaction, enabling the efficient synthesis of α,β-unsaturated carbonyl compounds. This makes it an indispensable material for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to construct complex molecular architectures with high stereoselectivity.

Application

• Pharmaceutical Intermediates: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing olefin linkages in drug candidates.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that require specific alkene functionalities.
• Specialty & Fine Chemicals: Employed in the manufacture of flavors, fragrances, dyes, and advanced materials where precise carbon-carbon double bond formation is crucial.
• Academic & Industrial R&D: A fundamental reagent in laboratory-scale organic synthesis and process chemistry for method development and scale-up studies.
• Ligand & Catalyst Preparation: Serves as a starting material for synthesizing phosphonate-based ligands used in coordination chemistry and catalysis.

Basic Information

Product Name	Diethyl (2-Oxopropyl)Phosphonate
CAS No.	1067-71-6
Molecular Formula	C7H15O4P
Molecular Weight	194.17 g/mol
Synonyms	Diethyl (2-Oxopropyl)Phosphonate; Diethyl (2-Oxopropyl)Phosphonate; Diethyl 2-Oxopropylphosphonate; (2-Oxopropyl)phosphonic Acid Diethyl Ester; Diethyl (3-Oxobutyl)Phosphonate; Acetonylphosphonic Acid Diethyl Ester; 1-Diethoxyphosphorylpropan-2-one; EINECS 213-935-5
EINECS	213-935-5

Quality Control

Our Diethyl (2-Oxopropyl)Phosphonate is produced under stringent quality management systems. Every batch undergoes comprehensive analytical testing including GC, HPLC, and NMR to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles to meet your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is between 15°C and 25°C. The container should be kept tightly sealed to minimize moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.430 - 1.435
Density (20°C)	1.10 - 1.15 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.