Description

Tri-p-Tolylphosphine is a versatile tertiary phosphine ligand widely used in organometallic chemistry and catalysis. Its primary value lies in its electron-donating properties and steric bulk, which are crucial for stabilizing metal complexes and enhancing catalytic activity in cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it serves as a key precursor for catalysts and specialty chemicals.

Application

• Catalyst Ligand in Cross-Coupling Reactions: A key component in palladium-catalyzed reactions such as Suzuki, Heck, and Stille couplings for C-C bond formation in complex organic synthesis.
• Pharmaceutical Intermediate Synthesis: Used in the production of active pharmaceutical ingredients (APIs) and fine chemicals requiring precise stereochemical control.
• Agrochemical Manufacturing: Employed in the synthesis of advanced pesticides and herbicides where specific ligand-metal complexes are required.
• Polymerization Catalyst Component: Acts as a ligand in transition metal catalysts for olefin polymerization and other polymer synthesis processes.
• Material Science Research: Utilized in the development of novel organometallic frameworks, metal-organic complexes, and electronic materials.
• Homogeneous Catalysis: Facilitates various homogeneous catalytic processes in both industrial and academic research settings.

Basic Information

Product Name	Tri-p-Tolylphosphine
CAS No.	1038-95-5
Molecular Formula	C21H21P
Molecular Weight	304.36 g/mol
Synonyms	Tris(4-methylphenyl)phosphine; Tri(4-tolyl)phosphine; Phosphine, tris(4-methylphenyl)-; Tris(p-tolyl)phosphine; P(p-Tol)3; 4-Methylphenylphosphine; Tri-para-tolylphosphine; Tris(4-methylphenyl)phosphane
EINECS	213-861-6

Quality Control

Our Tri-p-Tolylphosphine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is analyzed to confirm identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing specific results for purity, residual solvents, and heavy metals are provided with every shipment. We adhere to relevant industry standards and can support requirements for cGMP, ISO, and REACH compliance as needed.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its sensitivity to oxidation and light, prolonged exposure to air or light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	138 - 142 °C
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.