Description

1-Chloro-2,3-Dihydro-1H-Phosphole 1-Oxide is a versatile organophosphorus compound that serves as a key synthetic intermediate and ligand precursor in advanced chemical synthesis. Its unique heterocyclic structure, featuring a reactive P-Cl bond, makes it invaluable for constructing complex phosphorus-containing molecules. This high-purity chemical is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors seeking to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel phosphonate and phosphine oxide-based drug candidates, particularly in antiviral and anticancer research.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators that require specific phosphorus heterocycles for activity.
• Ligand Precursor: Serves as a starting material for the preparation of specialized phosphine ligands used in homogeneous catalysis, such as cross-coupling reactions.
• Material Science: Employed in the development of flame retardants, polymer modifiers, and other functional materials where phosphorus incorporation enhances properties.
• Organic Synthesis Research: A valuable reagent for academic and industrial R&D exploring new methodologies in heterocyclic and organophosphorus chemistry.

Basic Information

Product Name	1-Chloro-2,3-Dihydro-1H-Phosphole 1-Oxide
CAS No.	1003-18-5
Molecular Formula	C4H6ClOP
Molecular Weight	136.51 g/mol
Synonyms	1-Chloro-2,3-dihydro-1H-phosphole 1-oxide; 1-Chloro-2,5-dihydro-1H-phosphole 1-oxide; 1-Chlorophospholane 1-oxide; 1-Chloro-1-phospholene 1-oxide; Phospholane, 1-chloro-, 1-oxide; 1-Chloro-2,3-dihydrophosphole 1-oxide; 1-Chloro-δ³-phospholene 1-oxide
EINECS	Contact for details

Quality Control

Our production of 1-Chloro-2,3-Dihydro-1H-Phosphole 1-Oxide adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for your critical processes. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC to verify identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases. For long-term stability, storage under an inert atmosphere (e.g., nitrogen or argon) is recommended. The recommended storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.