Description

Mafenide Hydrochloride CAS NO 138-37-4 is a synthetic antibacterial agent belonging to the sulfonamide class. Its primary commercial value lies in its potent topical antimicrobial activity, particularly against a broad spectrum of gram-positive and gram-negative bacteria. This compound is essential for manufacturers in the pharmaceutical and medical device sectors, where it is utilized in the formulation of specialized wound care products and topical antiseptic preparations.

Application

• Topical Antibacterial Creams and Ointments: A key active pharmaceutical ingredient (API) in formulations for preventing and treating infections in burn wounds and skin grafts.
• Medical Device Coatings: Used to impart antimicrobial properties to wound dressings, surgical meshes, and other implantable materials to reduce the risk of biofilm formation.
• Veterinary Pharmaceuticals: Incorporated into topical preparations for treating bacterial skin infections in animals.
• Research & Development: Serves as a critical reference standard and intermediate in pharmacological research for developing new antimicrobial agents.
• Compounding Pharmacy: Utilized by specialized pharmacies to prepare customized topical medication formulations as per physician prescriptions.

Basic Information

Product Name	Mafenide Hydrochloride
CAS No.	138-37-4
Molecular Formula	C7H10ClN2O2S • HCl
Molecular Weight	247.14 g/mol
Synonyms	4-(Aminomethyl)benzenesulfonamide hydrochloride; Mafenide HCl; p-(Aminomethyl)benzenesulfonamide monohydrochloride; Sulfamylon Hydrochloride; Homosulfanilamide Hydrochloride; Marfanil Hydrochloride; NSC 11315; Para-(aminomethyl)benzenesulfonamide hydrochloride
EINECS	205-324-9

Quality Control

Our Mafenide Hydrochloride is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications, with specifications aligned with major pharmacopoeial guidelines. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to ensure traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. The product is hygroscopic (moisture-sensitive); ensure containers are sealed after each use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Microbial Enumeration	Meets Ph. Eur. / USP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.