Description

Z-L-Proline CAS NO 114-11-4 is a protected derivative of the amino acid L-proline, where the amine group is safeguarded by a carboxybenzyl (Cbz or Z) group. This protection is critical for enabling selective peptide bond formation in complex organic syntheses, particularly in the pharmaceutical and biotechnology sectors. It serves as a fundamental chiral building block for researchers and manufacturers developing peptide-based drugs, catalysts, and advanced biomaterials.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and protease inhibitors.
• Peptide Synthesis: Used extensively in solid-phase and solution-phase peptide synthesis (SPPS) as a protected amino acid to prevent unwanted side reactions.
• Asymmetric Catalysis: Employed as a precursor for chiral ligands and organocatalysts used in enantioselective synthesis.
• Biochemical Research: A vital reagent for studying enzyme mechanisms, protein structure, and for the preparation of custom peptides in life science research.
• Agrochemical Development: Utilized in the research and synthesis of novel, bioactive peptide-mimetic compounds for crop protection.

Basic Information

Product Name	Z-L-Proline
CAS No.	114-11-4
Molecular Formula	C13H15NO4
Molecular Weight	249.26 g/mol
Synonyms	N-Carbobenzoxy-L-proline; Cbz-L-Proline; N-Cbz-L-proline; (S)-1-((Benzyloxy)carbonyl)pyrrolidine-2-carboxylic acid; Z-Pro-OH; N-Benzyloxycarbonyl-L-proline; L-Proline, N-[(phenylmethoxy)carbonyl]-; NSC 3349
EINECS	204-048-6

Quality Control

Our Z-L-Proline is manufactured under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical and research applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]²⁰D	-58.0° to -62.0° (c=1 in AcOH)
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.