Description

Glycine Anhydride (CAS NO 106-57-0) is a high-purity cyclic dipeptide, also known as diketopiperazine, derived from the amino acid glycine. This versatile organic intermediate is valued for its rigid, planar structure and its role as a fundamental building block in advanced chemical synthesis. It is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where it serves as a key precursor for active pharmaceutical ingredients (APIs), peptide mimetics, and complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing a wide range of bioactive molecules, including protease inhibitors, kinase inhibitors, and other novel therapeutic agents.
• Peptidomimetics & Drug Discovery: Its diketopiperazine scaffold is extensively used in medicinal chemistry to create stable, conformationally restricted peptide analogs with improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced herbicides, fungicides, and plant growth regulators.
• Specialty Chemical Production: Used in the synthesis of chiral ligands, catalysts, and complex heterocyclic compounds for material science and fine chemical applications.
• Biochemical Research: Employed as a standard or model compound in studies of protein folding, peptide conformation, and enzyme-substrate interactions.

Basic Information

Product Name	Glycine Anhydride
CAS No.	106-57-0
Molecular Formula	C4H6N2O2
Molecular Weight	114.10 g/mol
Synonyms	2,5-Diketopiperazine; Diketopiperazine; Cyclo(glycyl-glycyl); Glycine cyclic dipeptide; 2,5-Piperazinedione; DKP; Gly-Gly anhydride; 1,4-Diaza-2,5-dioxocyclohexane
EINECS	203-411-2

Quality Control

Our Glycine Anhydride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure it meets the highest standards of purity and consistency for research and industrial use. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, assay, and impurity profiles. We support compliance with global regulatory frameworks, including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials. The product is hygroscopic (moisture-sensitive); ensure containers are sealed after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	310 - 315 °C (dec.)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.