Description

Diethyl 1,3-acetonedicarboxylate is a versatile diester compound widely used as a key building block in organic synthesis. Its value lies in its active methylene group, which readily undergoes condensation, alkylation, and cyclization reactions to form complex heterocyclic and carbocyclic structures. This high-purity intermediate is essential for research and production in the pharmaceutical, agrochemical, and fine chemical industries, enabling the synthesis of active ingredients and advanced materials.

Application

• Pharmaceutical Intermediates: A critical precursor in the synthesis of various heterocyclic compounds, including pyrimidines, pyridines, and coumarins, which are core structures in many active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the manufacturing of pesticides, herbicides, and fungicides, where it serves as a building block for creating complex molecular architectures with specific biological activity.
• Fine Chemical Production: Employed in the preparation of dyes, pigments, flavors, and fragrances due to its reactivity and ability to introduce specific functional groups.
• Academic & Industrial R&D: A fundamental reagent in research laboratories for method development, exploring new synthetic pathways, and creating novel chemical entities.
• Polymer Chemistry: Can be utilized as a monomer or cross-linking agent in the synthesis of specialty polymers and resins.

Basic Information

Product Name	Diethyl 1,3-Acetonedicarboxylate
CAS No.	105-50-5
Molecular Formula	C9H14O5
Molecular Weight	202.20 g/mol
Synonyms	Diethyl Acetonedicarboxylate; Diethyl 3-Oxoglutarate; 3-Oxoglutaric Acid Diethyl Ester; Acetonedicarboxylic Acid Diethyl Ester; 1,3-Acetonedicarboxylic Acid Diethyl Ester; Ethyl 3-Oxopentanedioate; Ethyl 3-Oxoglutarate; EINECS 203-305-9
EINECS	203-305-9

Quality Control

Our Diethyl 1,3-Acetonedicarboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chromatography (HPLC, GC) and spectroscopic methods, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment supports compliance with cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is moisture-sensitive; ensure containers are sealed after use to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.435 - 1.445
Density (20°C)	1.10 - 1.15 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.