Description

Diethyl 1,3-Acetonedicarboxylate is a versatile diester and a key building block in organic synthesis, valued for its active methylene group. This compound is essential for constructing complex molecular frameworks through condensation and cyclization reactions. It is primarily sought after by manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for the production of active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediates: A crucial precursor in the synthesis of heterocyclic compounds, including pyrimidines, pyridines, and various fused ring systems used in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Employed in the manufacturing of herbicides, fungicides, and insecticides, where it serves as a core component for constructing specific active moieties.
• Fine Chemical Production: Used in the synthesis of dyes, pigments, flavors, and fragrances due to its reactivity in Knoevenagel condensations and Michael additions.
• Chemical Research & Development: A fundamental reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel chemical entities.
• Polymer Chemistry: Can act as a monomer or cross-linking agent in the production of specialty polymers and resins.

Basic Information

Product Name	Diethyl 1,3-Acetonedicarboxylate
CAS No.	105-50-0
Molecular Formula	C9H14O5
Molecular Weight	202.20 g/mol
Synonyms	Diethyl Acetonedicarboxylate; Diethyl 3-Oxoglutarate; 3-Oxoglutaric Acid Diethyl Ester; Acetonedicarboxylic Acid Diethyl Ester; 1,3-Acetonedicarboxylic Acid Diethyl Ester; Ethyl 3-Oxopentanedioate; Diethyl β-Ketoglutarate; Ethyl Acetonedicarboxylate
EINECS	203-305-9

Quality Control

Our Diethyl 1,3-Acetonedicarboxylate is produced under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for sensitive synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.438 - 1.442
Density (g/mL, 20°C)	1.105 - 1.125

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.