Description

((1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((S)-1,1-dimethoxypropan-2-yl)-7a-methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)cyclohexane-1,3-diyl)bis(oxy)bis(tertbutyldimethylsilane) is a high-purity, advanced pharmaceutical intermediate featuring a complex, stereochemically defined structure. This compound is critical for the synthesis of novel therapeutic agents, particularly in the development of vitamin D analogs and other steroidal pharmaceuticals. It is essential for research institutions and pharmaceutical manufacturers engaged in cutting-edge drug discovery and process development, where precise molecular architecture is paramount for biological activity.

Application

• Key Intermediate in Vitamin D Analog Synthesis: Serves as a crucial building block for the production of calcitriol, paricalcitol, and other related therapeutic compounds.
• Pharmaceutical Research & Development (R&D): Used in medicinal chemistry for the design and synthesis of new chemical entities targeting nuclear hormone receptors.
• Process Chemistry & Scale-Up: Employed in the development and optimization of commercial-scale manufacturing routes for high-value active pharmaceutical ingredients (APIs).
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control in pharmaceutical analysis.
• Stereoselective Synthesis: Utilized in advanced organic synthesis to construct complex molecules with specific three-dimensional configurations.

Basic Information

Item	Details
Product Name	((1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((S)-1,1-dimethoxypropan-2-yl)-7a-methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)cyclohexane-1,3-diyl)bis(oxy)bis(tertbutyldimethylsilane)
CAS No.	957214-02-7
Molecular Formula	C34H62O4Si2
Molecular Weight	591.0 g/mol
Synonyms	1,3-Bis-O-(tert-butyldimethylsilyl)-5-[(E)-2-((1R,3aS,7aR)-1-[(S)-1,1-dimethoxypropan-2-yl]-7a-methyloctahydro-1H-inden-4-ylidene)ethylidene]cyclohexane-1,3-diol; TBS-protected Vitamin D intermediate; (1R,3R)-5-[(E)-2-((1R,3aS,7aR)-1-[(S)-1,1-Dimethoxypropan-2-yl]-7a-methyloctahydro-1H-inden-4-ylidene)ethylidene]cyclohexane-1,3-diyl bis(tert-butyldimethylsilyl) ether; Steroid synthesis intermediate 957214-02-7; Silyl ether protected CD-ring fragment.
EINECS	Contact for details

Quality Control

Our ((1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((S)-1,1-dimethoxypropan-2-yl)-7a-methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)cyclohexane-1,3-diyl)bis(oxy)bis(tertbutyldimethylsilane) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. Our products undergo rigorous quality testing, including chiral purity analysis, to ensure compliance with industry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled and stored away from strong alkali and organic solvents. For long-term storage, consider storing under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.