Description

(2S,3S,5R)-N-(2-((1S,2S,3S,5R,6R)-3,5-DIAZIDO-2-((2S,3R,4R,5S,6R)-3-AZIDO-6-(AZIDOMETHYL)-4,5-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLAMINO)ETHYL)-3-HYDROXY-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-2-CARBOXAMIDE is a sophisticated, multi-functional nucleoside analog derivative designed for advanced pharmaceutical research and development. This compound is of significant interest due to its complex, stereochemically defined structure, which incorporates multiple azido groups and a thymine base, making it a valuable click chemistry precursor and a key intermediate in the synthesis of novel antiviral and anticancer agents. It is primarily utilized by pharmaceutical R&D laboratories and biotech companies focused on developing next-generation therapeutics, particularly in the fields of nucleoside-based prodrugs and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel nucleoside analog prodrugs with potential antiviral or anticancer activity.
• Click Chemistry Reagent: The multiple azido (-N3) functional groups enable efficient, site-specific bioconjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling and drug targeting.
• Antiviral Research: Used as a precursor in the development of experimental therapeutics targeting viral polymerases (e.g., for HIV, Hepatitis).
• Oncology Drug Discovery: Investigated as an intermediate for creating compounds that interfere with DNA/RNA synthesis in rapidly dividing cancer cells.
• Bioconjugation & Probe Development: Facilitates the creation of fluorescent or affinity probes for studying biological pathways and target engagement.
• Academic & Institutional Research: Employed in universities and research institutes for studying nucleoside chemistry, enzyme inhibition, and structure-activity relationships (SAR).

Basic Information

Product Name	(2S,3S,5R)-N-(2-((1S,2S,3S,5R,6R)-3,5-DIAZIDO-2-((2S,3R,4R,5S,6R)-3-AZIDO-6-(AZIDOMETHYL)-4,5-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLAMINO)ETHYL)-3-HYDROXY-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-2-CARBOXAMIDE
CAS No.	948916-26-5
Molecular Formula	C24H34N14O11
Molecular Weight	694.62 g/mol
Synonyms	1-(3-Azido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione derivative; Multi-azido functionalized thymidine analog; Azido-modified nucleoside intermediate; CAS 948916-26-5; Click chemistry nucleoside precursor; Thymidine triazido derivative; Advanced pharmaceutical intermediate 948916-26-5
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and purity suitable for research applications. Our quality assurance includes comprehensive analytical characterization using techniques such as HPLC, NMR, and MS to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with each batch, documenting critical parameters. While not typically governed by compendial standards like USP/EP at this research stage, our production adheres to cGMP principles where applicable to support its use in pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This compound is strictly light-sensitive and should be handled under subdued light. Allow the container to reach ambient temperature before opening to minimize moisture condensation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.