Description

(2S,3S,4R,5R)-N-(3-((1S,2S,3S,5R,6R)-3,5-DIAZIDO-2-((2S,3R,4R,5S,6R)-3-AZIDO-6-(AZIDOMETHYL)-4,5-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLAMINO)PROPYL)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-CARBOXAMIDE is a sophisticated, multi-functional nucleoside analog derivative designed for advanced chemical synthesis and biological research. This compound is valued for its highly specific stereochemistry and the presence of multiple azido groups, making it a critical click chemistry intermediate and a versatile building block for drug discovery. It is primarily sought by researchers and process chemists in the pharmaceutical and biotechnology sectors for developing novel therapeutics, including antiviral and anticancer agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Click Chemistry Reagent: Utilized in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation, polymer modification, and materials science.
• Biochemical Probe Development: Used to create labeled analogs for studying enzyme mechanisms, nucleic acid interactions, and cellular processes.
• Glycobiology Research: Serves as a complex glycosyl donor or acceptor analog for synthesizing and studying modified carbohydrates and glycoconjugates.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the pharmacokinetic and pharmacodynamic properties of lead compounds.
• Process Chemistry & Scale-up: Used in route development and optimization for the commercial-scale production of specialty active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(2S,3S,4R,5R)-N-(3-((1S,2S,3S,5R,6R)-3,5-DIAZIDO-2-((2S,3R,4R,5S,6R)-3-AZIDO-6-(AZIDOMETHYL)-4,5-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLAMINO)PROPYL)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-CARBOXAMIDE
CAS No.	948916-17-4
Molecular Formula	C₂₈H₄₁N₁₅O₁₂
Molecular Weight	787.73 g/mol
Synonyms	1-(4-Azido-2,3-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-1-yl)pyrimidine-2,4(1H,3H)-dione derivative; Multi-azido functionalized nucleoside; Azido-modified uridine analog; Click chemistry nucleoside building block; CAS 948916-17-4; 5-Azidomethyl-2'-deoxyuridine triazide derivative; Complex nucleoside-cyclitol conjugate
EINECS	Contact for details

Quality Control

This high-value specialty chemical is produced under strict quality control protocols to ensure batch-to-batch consistency and reliability for research and development. Our quality assurance includes comprehensive analytical characterization using HPLC, NMR, and MS to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters. We support compliance with cGMP standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This compound is a strong oxidizer and moisture-sensitive; it must be kept dry and separated from reducing agents and combustible materials. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.