Description

N-{6-[(7S,9aS)-7-(hydroxymethyl)-octahydropyrazino[2,1-c][1,4]oxazin-8-yl]-4-(4-fluoro-2-methylphenyl)pyridin-3-yl}-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide is a sophisticated, high-purity pharmaceutical intermediate designed for advanced synthesis. This compound is critical for research and development in medicinal chemistry, particularly for targeting complex biological pathways. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) conditions.
• Contract Research & Manufacturing (CRAM): Supplied to service organizations supporting global drug discovery pipelines.
• Academic Research: Utilized in university and institutional labs for cutting-edge chemical biology and drug discovery projects.
• Bioconjugation & Probe Development: Potential use in creating chemical probes for target identification and validation studies.

Basic Information

Product Name	N-{6-[(7S,9aS)-7-(hydroxymethyl)-octahydropyrazino[2,1-c][1,4]oxazin-8-yl]-4-(4-fluoro-2-methylphenyl)pyridin-3-yl}-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide
CAS No.	929046-33-3
Molecular Formula	C₃₃H₃₃F₇N₄O₃
Molecular Weight	666.63 g/mol
Synonyms	929046-33-3; UNII-0F2C5B1Z7F; 0F2C5B1Z7F; N-[6-[(7S,9aS)-7-(Hydroxymethyl)hexahydro-2H-pyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide; Propanamide, N-[6-[(7S,9aS)-7-(hydroxymethyl)octahydro-2H-pyrazino[2,1-c][1,4]oxazin-8-yl]-4-(4-fluoro-2-methyl-3-pyridinyl]-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-; BMS-817378; BMS 817378
EINECS	Contact for details

Quality Control

Our N-{6-[(7S,9aS)-7-(hydroxymethyl)-octahydropyrazino[2,1-c][1,4]oxazin-8-yl]-4-(4-fluoro-2-methylphenyl)pyridin-3-yl}-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and rigorous control of residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. The compound is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere (argon or nitrogen) after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.