Description

(1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-[(2-pyrazinylcarbonyl)amino]acetyl]amino]-3,3-dimethyl-1-oxobutyl]octahydrocyclopenta[c]pyrrole-1-carboxylic acid tert-butyl ester is a sophisticated, high-purity pharmaceutical intermediate designed for advanced drug discovery and development. This compound is critical for researchers and manufacturers requiring precise, structurally complex building blocks for synthesizing novel therapeutic agents. It is primarily utilized in the pharmaceutical industry for the research and production of protease inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for protease inhibitor classes.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in early-stage R&D.
• Peptidomimetic Synthesis: Serves as a core scaffold for creating peptidomimetics that mimic natural peptides but with enhanced metabolic stability and bioavailability.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP production of clinical trial materials and commercial APIs.
• Academic Research: Utilized in university and institutional labs for biochemical studies involving enzyme inhibition and molecular target validation.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes from laboratory to pilot plant and commercial manufacturing scales.

Basic Information

Product Name	(1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-[(2-pyrazinylcarbonyl)amino]acetyl]amino]-3,3-dimethyl-1-oxobutyl]octahydrocyclopenta[c]pyrrole-1-carboxylic acid tert-butyl ester
CAS No.	926276-19-9
Molecular Formula	C31H47N5O6
Molecular Weight	585.74 g/mol
Synonyms	Boc-Pyrrolidine Derivative (926276-19-9); tert-Butyl (1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido]-3,3-dimethylbutanoyl]octahydrocyclopenta[c]pyrrole-1-carboxylate; Cyclopenta[c]pyrrole-1-carboxylic acid derivative; (2S)-2-[[(2S)-2-Cyclohexyl-2-[(pyrazin-2-ylcarbonyl)amino]acetyl]amino]-3,3-dimethylbutanoyl-(1S,3aR,6aS)-octahydrocyclopenta[c]pyrrol-2-yl-tert-butyl ester; Protease Inhibitor Intermediate; Peptidomimetic Scaffold 926276-19-9
EINECS	Contact for details

Quality Control

Our (1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-[(2-pyrazinylcarbonyl)amino]acetyl]amino]-3,3-dimethyl-1-oxobutyl]octahydrocyclopenta[c]pyrrole-1-carboxylic acid tert-butyl ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can align with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere if opened. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.