Description

(1R,2S)-2-Ethenyl-1-[[[(1R,2R,4R)-2-[(5-hexen-1-ylmethylamino)carbonyl]-4-[[7-methoxy-8-methyl-2-[4-Isopropyl-thiazol-2-yl]-quinolin-4-yl]oxy]cyclopentyl]carbonyl]amino]cyclopropane-carboxylic acid ethyl ester is a complex, high-purity chiral intermediate of significant interest in advanced pharmaceutical research and development. Its intricate molecular architecture, featuring a quinoline-thiazole core and multiple stereocenters, makes it a critical building block for the synthesis of novel therapeutic agents. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and process development of new drugs, particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of investigational new drug candidates.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Process Chemistry: Employed in the development and scale-up of synthetic routes for active pharmaceutical ingredients (APIs).
• Oncology Drug Discovery: Its structural motifs suggest potential application in the development of targeted cancer therapies.
• Custom Synthesis: A starting material for the preparation of more complex, proprietary analogs for biological screening.
• Academic Research: Used in universities and institutes studying advanced organic synthesis methodologies and asymmetric catalysis.

Basic Information

Product Name	(1R,2S)-2-Ethenyl-1-[[[(1R,2R,4R)-2-[(5-hexen-1-ylmethylamino)carbonyl]-4-[[7-methoxy-8-methyl-2-[4-Isopropyl-thiazol-2-yl]-quinolin-4-yl]oxy]cyclopentyl]carbonyl]amino]cyclopropane-carboxylic acid ethyl ester
CAS No.	923604-56-2
Molecular Formula	C₄₀H₅₀N₄O₆S
Molecular Weight	702.92 g/mol
Synonyms	Ethyl (1R,2S)-2-ethenyl-1-[[[(1R,2R,4R)-2-[(5-hexen-1-ylmethylamino)carbonyl]-4-[[7-methoxy-8-methyl-2-[4-(propan-2-yl)-1,3-thiazol-2-yl]quinolin-4-yl]oxy]cyclopentyl]carbonyl]amino]cyclopropane-1-carboxylate; 923604-56-2; UNII-8V6T5Q3Y0I; 8V6T5Q3Y0I; SCHEMBL21806217; DTXSID701330093; AKOS040757623; A-1058415.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity essential for research and development. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support compliance with ICH guidelines for impurities and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.