Description

2'-Deoxy-7-[(6aS,8R,9R,9aR)-1,2,3,6a,8,9,9a,11-octahydro-9-hydroxy-4-Methoxy-1,11-dioxocyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-8-yl]guanosine 3',5'-Dibutanoate is a high-purity, complex nucleoside derivative designed for advanced pharmaceutical research and development. This compound serves as a critical building block or intermediate in the synthesis of novel therapeutic agents, particularly in antiviral and anticancer drug discovery programs. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require structurally defined, high-quality intermediates to ensure the efficacy and safety of their final drug products.

Application

• Pharmaceutical Intermediate: Key starting material or advanced intermediate in the synthesis of novel nucleoside analog drugs.
• Antiviral Drug Research: Investigated for the development of new therapeutics targeting viral polymerases and replication mechanisms.
• Oncology Research: Used in the discovery and development of chemotherapeutic agents that interfere with DNA synthesis in cancer cells.
• Biochemical Research: Serves as a tool compound for studying enzyme kinetics, inhibition, and nucleoside metabolism pathways.
• Prodrug Development: The dibutanoate ester groups make it a candidate for prodrug strategies aimed at improving bioavailability and targeted delivery.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	2'-Deoxy-7-[(6aS,8R,9R,9aR)-1,2,3,6a,8,9,9a,11-octahydro-9-hydroxy-4-Methoxy-1,11-dioxocyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-8-yl]guanosine 3',5'-Dibutanoate
CAS No.	918446-34-1
Molecular Formula	C₃₄H₃₉N₅O₁₂
Molecular Weight	709.70 g/mol
Synonyms	7-(1,2,3,6a,8,9,9a,11-Octahydro-9-hydroxy-4-methoxy-1,11-dioxocyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-8-yl)-2'-deoxyguanosine 3',5'-dibutanoate; 2'-Deoxy-7-(9-hydroxy-4-methoxy-1,11-dioxo-1,2,3,6a,8,9,9a,11-octahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-8-yl)guanosine 3',5'-dibutyrate; Guanosine, 2'-deoxy-7-[(6aS,8R,9R,9aR)-1,2,3,6a,8,9,9a,11-octahydro-9-hydroxy-4-methoxy-1,11-dioxocyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-8-yl]-, 3',5'-dibutanoate
EINECS	Contact for details

Quality Control

Every batch of this advanced pharmaceutical intermediate is produced and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry to verify identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all critical quality attributes. Our commitment to cGMP-compliant practices ensures the material is suitable for use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.