Description

Carbamic acid, N-[[trans-4-[[(4-amino-6-chloro-2-pyrimidinyl)amino]methyl]cyclohexyl]methyl]-N-[3-[cyclohexyl[(1,1-dimethylethoxy)carbonyl]amino]propyl]-, 1,1-dimethylethyl ester is a sophisticated, high-purity chemical intermediate designed for advanced pharmaceutical synthesis. This compound is critical for research and development in medicinal chemistry, particularly in the construction of complex molecular scaffolds. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on producing novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in therapeutic areas requiring complex heterocyclic structures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes during drug discovery.
• Protease Inhibitor Synthesis: Serves as a precursor in the development of enzyme inhibitors, leveraging its carbamate and pyrimidine functional groups.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the production of specialized, high-value compounds under cGMP conditions.
• Bioconjugation & Linker Chemistry: Potential use in creating cleavable linkers for antibody-drug conjugates (ADCs) or other targeted therapies.
• Chemical Biology Probes: Useful for developing molecular probes to study biological pathways and protein functions.

Basic Information

Product Name	Carbamic acid, N-[[trans-4-[[(4-amino-6-chloro-2-pyrimidinyl)amino]methyl]cyclohexyl]methyl]-N-[3-[cyclohexyl[(1,1-dimethylethoxy)carbonyl]amino]propyl]-, 1,1-dimethylethyl ester
CAS No.	917022-13-0
Molecular Formula	C32H53ClN6O4
Molecular Weight	621.26 g/mol
Synonyms	tert-Butyl N-[3-[N-(tert-butoxycarbonyl)-N-cyclohexylamino]propyl]-N-[[trans-4-[[(4-amino-6-chloro-2-pyrimidinyl)amino]methyl]cyclohexyl]methyl]carbamate; 1,1-Dimethylethyl N-[[trans-4-[[(4-amino-6-chloro-2-pyrimidinyl)amino]methyl]cyclohexyl]methyl]-N-[3-[cyclohexyl[(1,1-dimethylethoxy)carbonyl]amino]propyl]carbamate; BOC-protected amino pyrimidine cyclohexylmethyl carbamate; CAS 917022-13-0; tert-Butyl (trans-4-(((4-amino-6-chloropyrimidin-2-yl)amino)methyl)cyclohexyl)methyl(3-(cyclohexyl((tert-butoxy)carbonyl)amino)propyl)carbamate
EINECS	Contact for details

Quality Control

Our Carbamic acid, N-[[trans-4-[[(4-amino-6-chloro-2-pyrimidinyl)amino]methyl]cyclohexyl]methyl]-N-[3-[cyclohexyl[(1,1-dimethylethoxy)carbonyl]amino]propyl]-, 1,1-dimethylethyl ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light) and should be handled in a well-ventilated area. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.