Description

(1R,3S,E)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-Methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-Methylenecyclohexane-1,3-diol is a high-purity, stereochemically defined synthetic intermediate of significant importance in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of complex, biologically active molecules, particularly in the field of vitamin D analogs and other sterol-based therapeutics. It is essential for pharmaceutical companies, biotechnology firms, and advanced contract research organizations (CROs) engaged in the development of novel drugs targeting metabolic and endocrine pathways.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of novel Vitamin D receptor (VDR) modulators and analogs.
• Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Serves as a critical intermediate in the scale-up and process development for active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in studies investigating sterol metabolism, nuclear receptor signaling, and calcium homeostasis.
• Reference Standard: Utilized as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Product Name	(1R,3S,E)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-Methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-Methylenecyclohexane-1,3-diol
CAS No.	910133-70-9
Molecular Formula	C30H44O3
Molecular Weight	452.67 g/mol
Synonyms	Vitamin D3 Intermediate CD Ring Fragment; (23S,25R)-1α,25-Dihydroxy-26,27-cyclopropylvitamin D3 Advanced Intermediate; (1R,3S,5E)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,5S,6E)-5-Cyclopropyl-5-hydroxy-6-hexen-2-yl]-7a-methyloctahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol; 1α,25-Dihydroxy-26,27-cyclopropyl-19-nor-previtamin D3; Sterol CD Ring Synthon; 26,27-Cyclopropyl Vitamin D Analog Intermediate
EINECS	Contact for details

Quality Control

Our (1R,3S,E)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-Methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-Methylenecyclohexane-1,3-diol is manufactured under strict quality management systems. Products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure high stereochemical purity and chemical identity. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with each batch to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.