Description

9(2R,5S,6R)]-18-Deoxo-3-deoxy-4B-O-[(1,1-dimethylethyl)dimethyisilyl]-18-[[(1,1-dimethylethyl)dimethyisilyl]oxy]-3,18-epoxy-9-O-[tetrahydro-6-methyl-5-(methylamino)-2H-pyran-2-yl]-leucomycin V 2B-Acetate is a chemically modified derivative of the macrolide antibiotic leucomycin, specifically engineered as a key advanced pharmaceutical intermediate for research and synthesis. This compound is critical for the development of novel antibacterial agents, offering a versatile scaffold for further chemical modifications. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on antibiotic discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthetic pathway for novel macrolide antibiotics and semi-synthetic derivatives.
• Antibacterial Research: Used in biochemical and microbiological research to study structure-activity relationships (SAR) and mechanisms of action against resistant bacterial strains.
• Process Chemistry Development: Serves as a standard or reference material for optimizing large-scale synthesis and purification processes in API (Active Pharmaceutical Ingredient) manufacturing.
• Academic & Institutional Research: Employed in university and institutional labs for medicinal chemistry projects targeting infectious diseases.
• Custom Synthesis: A starting material for the contract synthesis of specialized, high-value chemical entities for preclinical studies.

Basic Information

Product Name	9(2R,5S,6R)]-18-Deoxo-3-deoxy-4B-O-[(1,1-dimethylethyl)dimethyisilyl]-18-[[(1,1-dimethylethyl)dimethyisilyl]oxy]-3,18-epoxy-9-O-[tetrahydro-6-methyl-5-(methylamino)-2H-pyran-2-yl]-leucomycin V 2B-Acetate
CAS No.	96405-33-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	18-Deoxo-3-deoxy-4B-O-(tert-butyldimethylsilyl)-18-[(tert-butyldimethylsilyl)oxy]-3,18-epoxy-9-O-[tetrahydro-6-methyl-5-(methylamino)-2H-pyran-2-yl]leucomycin V 2B-Acetate; TBDMS-Leucomycin V Derivative; Silylated Leucomycin V Intermediate; 9-O-[(5-Methylamino)tetrahydropyran-2-yl]leucomycin Derivative; CAS 96405-33-3; Leucomycin V 2B-Acetate, 18-deoxo-3-deoxy-4B-O-(tert-butyldimethylsilyl)-18-[(tert-butyldimethylsilyl)oxy]-3,18-epoxy-9-O-[tetrahydro-6-methyl-5-(methylamino)-2H-pyran-2-yl]-; (2R,5S,6R)-Configured Leucomycin Intermediate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for advanced pharmaceutical intermediates. All batches are characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We adhere to GMP-grade handling and documentation practices for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be kept in a dry environment. Avoid exposure to fluoride compounds and strong alkali.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.