Description

[9(2R,5S,6R)]-18-Deoxo-3-deoxy-9-O-[5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]-4B-O-[(1,1-dimethylethyl)dimethylsilyl]-18-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,18-epoxy-leucomycin V 2B-Acetate is a chemically modified derivative of the macrolide antibiotic leucomycin, featuring specific protective silyl ether groups. This advanced intermediate is of critical importance for pharmaceutical research and development, particularly in the synthesis of novel antibacterial agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of next-generation macrolide antibiotics.

Application

• Key Intermediate in Antibiotic Synthesis: Serves as a crucial building block for the semi-synthesis of novel leucomycin and related macrolide antibiotic analogs.
• Pharmaceutical Research & Development: Used in medicinal chemistry programs to study structure-activity relationships (SAR) and develop new antibacterial compounds with improved efficacy or spectrum.
• Process Chemistry & Scale-Up: Employed in the development and optimization of synthetic routes for complex macrolide molecules at pilot and commercial scales.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in antibiotic manufacturing.
• Biochemical Research: Applied in studies investigating the mechanism of action and resistance of macrolide antibiotics.

Basic Information

Product Name	[9(2R,5S,6R)]-18-Deoxo-3-deoxy-9-O-[5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]-4B-O-[(1,1-dimethylethyl)dimethylsilyl]-18-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,18-epoxy-leucomycin V 2B-Acetate
CAS No.	96405-32-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	18-Deoxo-3-deoxy-9-O-[5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]-4B-O-(tert-butyldimethylsilyl)-18-[(tert-butyldimethylsilyl)oxy]-3,18-epoxy-leucomycin V 2B-acetate; TBDMS-protected Leucomycin V Derivative; Silylated Leucomycin Intermediate; 3,18-Epoxy-leucomycin V 2B-acetate derivative; CAS 96405-32-2
EINECS	Contact for details

Quality Control

Our [9(2R,5S,6R)]-18-Deoxo-3-deoxy-9-O-[5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]-4B-O-[(1,1-dimethylethyl)dimethylsilyl]-18-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,18-epoxy-leucomycin V 2B-Acetate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical characterization using techniques such as HPLC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.