Description

(R)-Methyl 4-((3R,5S,8S,9S,10S,13R,14S,17R)-3-(tert-butyldimethylsilyloxy)-10,13-dimethyl-7-(trimethylsilyloxy)-2,3,4,5,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate is a high-purity, stereochemically defined steroid derivative featuring dual silyl protecting groups. This compound is a critical chiral intermediate in advanced pharmaceutical synthesis, enabling the production of complex therapeutic agents with high enantiomeric purity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of steroidal drugs, hormone therapies, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex steroidal active pharmaceutical ingredients (APIs).
• Steroid Research: Used in academic and industrial research for developing novel hormone analogs and receptor modulators.
• Process Chemistry: Serves as a protected intermediate in multi-step synthetic routes for scale-up and process optimization.
• Biochemical Studies: Employed in the study of steroid biosynthesis pathways and enzyme inhibition.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control.

Basic Information

Product Name	(R)-Methyl 4-((3R,5S,8S,9S,10S,13R,14S,17R)-3-(tert-butyldimethylsilyloxy)-10,13-dimethyl-7-(trimethylsilyloxy)-2,3,4,5,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate
CAS No.	91097-40-4
Molecular Formula	C36H66O4Si2
Molecular Weight	619.08 g/mol
Synonyms	Methyl (17R)-4-[(3R,5S,8S,9S,10S,13R,14S,17R)-3-[(1,1-Dimethylethyl)dimethylsilyl]oxy-10,13-dimethyl-7-(trimethylsilyloxy)-2,3,4,5,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate; 3β-(tert-Butyldimethylsilyloxy)-7α-(trimethylsilyloxy)-5α-androstan-17β-yl methyl pentanoate derivative; TBDMS/TMS-protected steroid intermediate; (R)-Methyl 4-((3R,5S,8S,9S,10S,13R,14S,17R)-3-((tert-butyldimethylsilyl)oxy)-10,13-dimethyl-7-((trimethylsilyl)oxy)hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate
EINECS	Contact for details

Quality Control

Our (R)-Methyl 4-((3R,5S,8S,9S,10S,13R,14S,17R)-3-(tert-butyldimethylsilyloxy)-10,13-dimethyl-7-(trimethylsilyloxy)-2,3,4,5,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.