Description

(1aS,1bS,2S,5aR,6S,6aS)-1a-(hydroxymethyl)-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1a,1b,2,5a,6,6a-hexahydrooxireno[2',3':4,5]cyclopenta[1,2-c]pyran-6-yl 4-methoxybenzoate is a complex, high-purity synthetic intermediate with significant potential in advanced pharmaceutical research and development. This compound is valued for its intricate stereochemistry and functional groups, which make it a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex drug candidates, particularly in oncology and antiviral research.
• Chemical Biology Research: Used as a probe or precursor in studying biological pathways and enzyme interactions due to its glycosidic and benzoate ester functionalities.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions for clinical trial material production.
• Reference Standard: Employed as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Medicinal Chemistry: Utilized in structure-activity relationship (SAR) studies to optimize the potency and selectivity of new chemical entities.

Basic Information

Item	Details
Product Name	(1aS,1bS,2S,5aR,6S,6aS)-1a-(hydroxymethyl)-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1a,1b,2,5a,6,6a-hexahydrooxireno[2',3':4,5]cyclopenta[1,2-c]pyran-6-yl 4-methoxybenzoate
CAS No.	887140-17-2
Molecular Formula	C24H28O12
Molecular Weight	508.47 g/mol
Synonyms	Paclitaxel C-13 side chain benzoate derivative; Taxol intermediate derivative; 2'-O-(4-Methoxybenzoyl)taxol C-13 side chain glycoside; (2R,3S)-3-((Benzoyloxy)-2-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)pentanedioic acid derivative; Oxireno[2',3':4,5]cyclopenta[1,2-c]pyran-6-yl 4-methoxybenzoate glycoside; Advanced paclitaxel synthetic precursor; 4-Methoxybenzoate ester of a taxane side chain sugar.
EINECS	Contact for details

Quality Control

This high-value intermediate is produced and controlled under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry for identity verification. We provide full traceability and detailed Certificates of Analysis (COA) to support your regulatory and research requirements. Specifications are aligned with the needs of pre-clinical and clinical-stage pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.