Description

3-Piperidinecarboxylic acid, 1-[(2S)-2-[[2-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-1-oxopropyl]amino]-3-(1H-indol-3-yl)-1-oxopropyl]-3-(phenylmethyl)-, 1,2,2-trimethylhydrazide, (3R)- is a sophisticated, high-purity chemical intermediate characterized by its complex chiral structure. This compound is of critical importance in modern pharmaceutical research and development, particularly in the synthesis of targeted therapeutics. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing novel active pharmaceutical ingredients (APIs). Its specific stereochemistry and functional groups make it a valuable building block for advanced medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key chiral building block in the research and synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Protease Inhibitor Research: Used in the development of inhibitors for specific enzymatic targets due to its peptide-like backbone and protective groups.
• Peptidomimetic Chemistry: Serves as a core scaffold for designing and synthesizing peptidomimetics, which are molecules that mimic peptides but with enhanced stability and bioavailability.
• Process Chemistry & Scale-Up: Employed in the optimization and scale-up of synthetic routes for potential Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) guidelines.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the global pharmaceutical development pipeline.

Basic Information

Item	Detail
Product Name	3-Piperidinecarboxylic acid, 1-[(2S)-2-[[2-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-1-oxopropyl]amino]-3-(1H-indol-3-yl)-1-oxopropyl]-3-(phenylmethyl)-, 1,2,2-trimethylhydrazide, (3R)-
CAS No.	883572-59-6
Molecular Formula	C36H49N5O6
Molecular Weight	647.81 g/mol
Synonyms	(3R)-1-[(2S)-2-[[2-[(tert-Butoxycarbonyl)amino]-2-methylpropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]-3-benzylpiperidine-1,2,2-trimethylhydrazide; Boc-L-α-methylTrp-N-Me-N'-N'-dimethylhydrazide derivative; Advanced Chiral Piperidine Intermediate; Protected Amino Acid Hydrazide Derivative; Pharmaceutical Building Block 883572-59-6; tert-Butyl (1-{[(2S)-1-[(3R)-3-benzyl-1,2,2-trimethylhydrazinecarbonyl]piperidin-3-yl]-3-(1H-indol-3-yl)-1-oxopropan-2-yl}amino)-2-methyl-1-oxopropan-2-yl]carbamate
EINECS	Contact for details

Quality Control

We supply this high-value intermediate with a strong commitment to purity and batch-to-batch consistency, essential for sensitive pharmaceutical R&D. Our quality assurance protocol includes comprehensive analytical characterization using techniques such as HPLC, NMR, and MS to confirm identity, chiral purity, and chemical purity. A detailed Certificate of Analysis (COA) is provided with each batch, documenting critical specifications. While typically supplied as a research-grade material, production can be aligned with GMP standards for advanced development phases upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The product is moisture-sensitive and should be handled in a dry environment. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.