Description

(3S,4S,4aS,5R)-6-[[(3S,5S)-5-[[(3-Carboxyphenyl)aMino]carbonyl]-3-pyrrolidinyl]thio]-3,4,4a,5-tetrahydro-3,5-diMethyl-1-oxo-1H-pyrrolo[1,2-c][1,3]oxazine-4,7-dicarboxylic Acid is a sophisticated chiral organic compound featuring a complex polycyclic structure with multiple carboxylic acid groups. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting specific biological pathways. It is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries who require building blocks with precise stereochemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of complex drug candidates, particularly for central nervous system (CNS) and anti-infective therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its defined stereochemistry and functional group diversity.
• Process Chemistry Development: Employed in scaling up synthetic routes for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Bioconjugation & Probe Synthesis: The carboxylic acid groups and unique scaffold make it suitable for creating labeled probes or conjugates for biochemical assays.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) engaged in advanced organic synthesis and drug discovery projects.

Basic Information

Product Name	(3S,4S,4aS,5R)-6-[[(3S,5S)-5-[[(3-Carboxyphenyl)aMino]carbonyl]-3-pyrrolidinyl]thio]-3,4,4a,5-tetrahydro-3,5-diMethyl-1-oxo-1H-pyrrolo[1,2-c][1,3]oxazine-4,7-dicarboxylic Acid
CAS No.	866186-68-7
Molecular Formula	C24H25N3O9S
Molecular Weight	531.54 g/mol
Synonyms	Pyrrolo[1,2-c][1,3]oxazine-4,7-dicarboxylic acid derivative; (3S,4S,4aS,5R)-6-(((3S,5S)-5-(3-Carboxybenzamido)-3-pyrrolidinyl)thio)-3,4,4a,5-tetrahydro-3,5-dimethyl-1-oxo-1H-pyrrolo[1,2-c][1,3]oxazine-4,7-dicarboxylic acid; CAS 866186-68-7; 1H-Pyrrolo[1,2-c][1,3]oxazine-4,7-dicarboxylic acid, 6-[[(3S,5S)-5-[[(3-carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-3,4,4a,5-tetrahydro-3,5-dimethyl-1-oxo-, (3S,4S,4aS,5R)-
EINECS	Contact for details

Quality Control

Our (3S,4S,4aS,5R)-6-[[(3S,5S)-5-[[(3-Carboxyphenyl)aMino]carbonyl]-3-pyrrolidinyl]thio]-3,4,4a,5-tetrahydro-3,5-diMethyl-1-oxo-1H-pyrrolo[1,2-c][1,3]oxazine-4,7-dicarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.