Description

(2R)-2-[([1,1μ-Biphenyl]-4-ylsulfonyl)(1-methylethoxy)amino]-N-hydroxy-3-methyl-butanamide, also known as (R)-N-Hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamide, is a high-purity, chiral hydroxamic acid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block and a potent pharmacophore, primarily functioning as a selective enzyme inhibitor. It is essential for medicinal chemists and R&D teams focused on developing novel therapeutic agents, particularly in oncology and inflammatory disease pathways. The product is supplied to meet the stringent demands of preclinical and process chemistry applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of targeted small-molecule drugs, especially histone deacetylase (HDAC) inhibitors.
• Biochemical Research: Used as a reference standard and active probe in enzymatic assays and mechanism-of-action studies.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) optimization in drug discovery programs.
• Preclinical Development: Employed in the production of batches for pharmacokinetic, pharmacodynamic, and toxicology studies.
• Process Chemistry: Utilized in route scouting and scale-up development for active pharmaceutical ingredient (API) manufacturing.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug development pipelines.

Basic Information

Product Name	(2R)-2-[([1,1μ-Biphenyl]-4-ylsulfonyl)(1-methylethoxy)amino]-N-hydroxy-3-methyl-butanamide
CAS No.	849773-64-4
Molecular Formula	C21H28N2O5S
Molecular Weight	420.52 g/mol
Synonyms	(R)-N-Hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamide; (R)-N-Hydroxy-3-methyl-2-[(4-phenylphenyl)sulfonyl-(propan-2-yloxy)amino]butanamide; 849773-64-4; Biphenyl-4-sulfonic acid [1-(hydroxycarbamoyl)-2-methyl-propyl]-isopropoxy-amide, (2R)-; HDAC Inhibitor Intermediate; Chiral Hydroxamic Acid Derivative; Sulfonamide Hydroxamate
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Quality is verified through advanced analytical techniques including HPLC, chiral analysis, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support compliance with ICH guidelines for stability and impurity characterization.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). For long-term storage, consider storing under an inert gas such as argon or nitrogen in a sealed container. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.