Description

(6R,7R)-7-[(2-Bromoacetyl)amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Diphenylmethyl Ester is a sophisticated cephalosporin intermediate designed for advanced pharmaceutical synthesis. This compound is critical for researchers and manufacturers developing next-generation β-lactam antibiotics, offering a key structural handle for further chemical modification. It is primarily utilized by the pharmaceutical and biotechnology industries for the research and production of novel antibacterial agents.

Application

• Key Intermediate in Antibiotic Synthesis: Serves as a crucial building block in the multi-step synthesis of advanced cephalosporin antibiotics.
• Pharmaceutical Research & Development (R&D): Used in medicinal chemistry for the discovery and optimization of new antibacterial compounds with improved efficacy and spectrum.
• Process Chemistry & Scale-Up: Employed in the development and optimization of manufacturing routes for active pharmaceutical ingredients (APIs).
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical production.
• Synthesis of Prodrugs: The diphenylmethyl ester (DPM) protecting group allows for targeted deprotection in the final stages of API synthesis.
• Academic Research: Used in university and institutional labs for studying β-lactam chemistry, antibiotic resistance mechanisms, and novel synthetic methodologies.

Basic Information

Product Name	(6R,7R)-7-[(2-Bromoacetyl)amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Diphenylmethyl Ester
CAS No.	816451-58-8
Molecular Formula	C25H25BrN6O5S2
Molecular Weight	633.54 g/mol
Synonyms	7-[(2-Bromoacetyl)amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester; Cephalosporin DPM Ester Intermediate; 7-ACA DPM Ester Derivative; (6R,7R)-3-[(1-Methyl-1H-tetrazol-5-ylthio)methyl]-7-[(2-bromoacetamido)]-7-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester; 7-Bromoacetamido-7-methoxycephalosporanic acid DPM ester
EINECS	Contact for details

Quality Control

Our (6R,7R)-7-[(2-Bromoacetyl)amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Diphenylmethyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical R&D and synthesis. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.