Description

(1R,7E)-1β,8aα,12α-Trimethyl-4β-chloro-5-methylene-6β,12,13β-triacetoxy-13aβ-hydroxy-1,2,3aα,4,5,6,8a,11,12,12aβ,13,13a-dodecahydrobenzo[4,5]cyclodeca[1,2-b]furan-2,11-dione is a complex, highly functionalized diterpenoid derivative with significant potential as a key synthetic intermediate. Its intricate polycyclic structure, featuring multiple chiral centers and reactive functional groups, makes it a valuable scaffold for advanced organic synthesis and medicinal chemistry research. This compound is primarily targeted at R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a sophisticated building block for the synthesis of novel drug candidates, particularly in oncology, anti-inflammatory, and anti-infective therapeutic areas.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to explore new chemical entities and optimize biological activity.
• Natural Product Synthesis: Acts as a key intermediate in the total or semi-synthesis of complex natural products with diterpenoid backbones.
• Agrochemical Development: Employed in research for creating new plant growth regulators or pesticides with novel modes of action.
• Chemical Biology Probes: Utilized to develop molecular probes for studying biological pathways and target identification.
• Process Chemistry & Scale-up: Supports route scouting and optimization studies for the efficient production of high-value target molecules.

Basic Information

Product Name	(1R,7E)-1β,8aα,12α-Trimethyl-4β-chloro-5-methylene-6β,12,13β-triacetoxy-13aβ-hydroxy-1,2,3aα,4,5,6,8a,11,12,12aβ,13,13a-dodecahydrobenzo[4,5]cyclodeca[1,2-b]furan-2,11-dione
CAS No.	89999-15-5
Molecular Formula	C28H33ClO11
Molecular Weight	581.01 g/mol
Synonyms	4β-Chloro-5-methylene-6β,12,13β-triacetoxy-13aβ-hydroxy-1,2,3aα,4,5,6,8a,11,12,12aβ,13,13a-dodecahydro-1β,8aα,12α-trimethylbenzo[4,5]cyclodeca[1,2-b]furan-2,11-dione; (1R,7E)-Taxinine B 13-Acetate Chloro Derivative; 13-Acetyl-4-deacetyl-2-debenzoyltaxinine B chloro derivative; A Diterpenoid Furan Derivative; Benzo[4,5]cyclodeca[1,2-b]furan-2,11-dione, dodecahydro derivative; CAS 89999-15-5
EINECS	Contact for details

Quality Control

Our (1R,7E)-1β,8aα,12α-Trimethyl-4β-chloro-5-methylene-6β,12,13β-triacetoxy-13aβ-hydroxy-1,2,3aα,4,5,6,8a,11,12,12aβ,13,13a-dodecahydrobenzo[4,5]cyclodeca[1,2-b]furan-2,11-dione is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.