Description

(1S,3S,4E)-4-[(2E)-2-[(1R,3aR,7aS)-1-[(E,2S)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-6-methylidene-cyclohexane-1,3-diol is a high-purity, synthetically derived vitamin D analog with significant biological activity. This compound is crucial for advanced research and development in the life sciences, particularly for studying calcium metabolism, cell differentiation, and immune system regulation. It is primarily sought by pharmaceutical R&D teams, academic research institutions, and manufacturers of high-value active pharmaceutical ingredients (APIs) and reference standards.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel vitamin D receptor (VDR) agonists and other therapeutic analogs.
• Biochemical Research: Used as a reference standard and a potent tool compound for investigating VDR signaling pathways, gene expression, and cellular proliferation.
• API Development: Serves as a critical precursor in the development of new drug candidates targeting osteoporosis, psoriasis, and certain cancers.
• Cell Culture Studies: Employed in in vitro studies to examine the effects of vitamin D analogs on cell growth, differentiation, and function.
• Metabolic Studies: Utilized in preclinical research to understand the metabolism and pharmacokinetics of vitamin D-related compounds.
• High-Purity Reference Material: Supplied as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.

Basic Information

Product Name	(1S,3S,4E)-4-[(2E)-2-[(1R,3aR,7aS)-1-[(E,2S)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-6-methylidene-cyclohexane-1,3-diol
CAS No.	87649-67-0
Molecular Formula	C30H46O2
Molecular Weight	438.69 g/mol
Synonyms	1α,25-Dihydroxy-26,27-dimethyl-20,21-didehydro-19-norvitamin D3; 1α,25-Dihydroxy-26,27-dimethyl-19-nor-20,21-didehydrovitamin D3; 2-Methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 analog; 2MD; 2-Methylene-19-nor-1α,25-dihydroxyvitamin D3; 2-Methylene-19-nor-(20S)-1α,25-(OH)2D3; 2α-Methylene-19-nor-1α,25-dihydroxyvitamin D3; 2-Methylene-19-nor-1α,25-dihydroxyvitamin D3 (2MD)
EINECS	Contact for details

Quality Control

Our (1S,3S,4E)-4-[(2E)-2-[(1R,3aR,7aS)-1-[(E,2S)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-6-methylidene-cyclohexane-1,3-diol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and potency meet rigorous standards suitable for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled environment to prevent degradation. For long-term storage, consider storage under argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.