Description

[1R,6R,(+)]-1α-[[(1S,4aR)-Decahydro-6β-hydroxy-5,5,8aβ-trimethyl-2-methylenenaphthalene-1β-yl]methyl]-5β-hydroxy-4-(hydroxymethyl)-7-oxabicyclo[4.1.0]hepta-3-ene-2-one CAS NO 85764-11-0 is a high-purity, complex sesquiterpene lactone derivative with a defined stereochemistry. This compound is valued for its role as a critical advanced pharmaceutical intermediate and a versatile scaffold in organic synthesis. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel therapeutic agents, particularly in anti-inflammatory and anticancer research.
• Organic Synthesis Reagent: Serves as a sophisticated chiral starting material or intermediate for complex natural product synthesis and medicinal chemistry programs.
• Biochemical Research: Used as a reference standard or probe in enzymatic studies and biological pathway investigations due to its specific stereochemical configuration.
• Agrochemical Development: Potential intermediate in the research and development of new crop protection agents with specific modes of action.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring high stereochemical purity.

Basic Information

Product Name	[1R,6R,(+)]-1α-[[(1S,4aR)-Decahydro-6β-hydroxy-5,5,8aβ-trimethyl-2-methylenenaphthalene-1β-yl]methyl]-5β-hydroxy-4-(hydroxymethyl)-7-oxabicyclo[4.1.0]hepta-3-ene-2-one
CAS No.	85764-11-0
Molecular Formula	C24H36O5
Molecular Weight	404.54 g/mol
Synonyms	(+)-1α-[[(1S,4aR)-Decahydro-6β-hydroxy-5,5,8aβ-trimethyl-2-methylenenaphthalen-1β-yl]methyl]-5β-hydroxy-4-(hydroxymethyl)-7-oxabicyclo[4.1.0]hept-3-en-2-one; 1R,6R-(+)-Isomer of a Parthenolide derivative; 7-Oxabicyclo[4.1.0]hepta-3-ene-2-one, 1-[[(1S,4aR)-decahydro-6-hydroxy-5,5,8a-trimethyl-2-methylene-1-naphthalenyl]methyl]-4-(hydroxymethyl)-5-hydroxy-, (1R,6R)-; Sesquiterpene lactone intermediate; Advanced Parthenolide analog; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of [1R,6R,(+)]-1α-[[(1S,4aR)-Decahydro-6β-hydroxy-5,5,8aβ-trimethyl-2-methylenenaphthalene-1β-yl]methyl]-5β-hydroxy-4-(hydroxymethyl)-7-oxabicyclo[4.1.0]hepta-3-ene-2-one adheres to stringent quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive) and easily oxidized; containers must be kept tightly sealed in a cool, dry place to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.