Description

CyclopentaneMethanol, 2-[[3-[[(1,1-diMethylethyl)diMethylsilyl]oxy]phenyl]Methyl]-4-[(tetrahydro-2 H-pyran-2-yl)oxy]-3-[3-[(tetrahydro-2H-pyran-2-yl)oxy]-1-octenyl]-, Methanesulfonate, [1S-[1a,2a,3b(1E,3R*),4a]]- is a sophisticated, high-purity synthetic intermediate characterized by its complex stereochemistry and protective group chemistry. This compound is of critical importance in advanced organic synthesis, particularly for constructing complex molecular architectures where precise stereocontrol and functional group manipulation are required. It serves as a key building block for research and development chemists in the pharmaceutical and agrochemical industries, enabling the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for complex targets.
• Agrochemical Synthesis: Used in the development of advanced crop protection agents and pesticides requiring specific stereochemistry for efficacy.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale production of fine chemicals.
• Academic & Institutional Research: Serves as a valuable tool for methodology development in organic synthesis, asymmetric catalysis, and total synthesis projects.
• Custom Synthesis & Contract Manufacturing: A starting material for specialized custom synthesis services catering to biotechnology and chemical companies.
• Protecting Group Strategy: Its structure, featuring silyl and tetrahydropyranyl (THP) protecting groups, makes it an instructive example and practical reagent in multi-step synthetic sequences.

Basic Information

Product Name	CyclopentaneMethanol, 2-[[3-[[(1,1-diMethylethyl)diMethylsilyl]oxy]phenyl]Methyl]-4-[(tetrahydro-2 H-pyran-2-yl)oxy]-3-[3-[(tetrahydro-2H-pyran-2-yl)oxy]-1-octenyl]-, Methanesulfonate, [1S-[1a,2a,3b(1E,3R*),4a]]-
CAS No.	81846-27-7
Molecular Formula	C39H64O8SSi
Molecular Weight	721.07 g/mol
Synonyms	(1S,2S,3R,4S)-2-[[3-[(tert-Butyldimethylsilyl)oxy]phenyl]methyl]-4-[(tetrahydro-2H-pyran-2-yl)oxy]-3-[3-[(tetrahydro-2H-pyran-2-yl)oxy]-1-octen-1-yl]cyclopentylmethyl methanesulfonate; (1S,2S,3R,4S)-2-({3-[(tert-Butyldimethylsilyl)oxy]phenyl}methyl)-4-[(oxan-2-yl)oxy]-3-{3-[(oxan-2-yl)oxy]oct-1-en-1-yl}cyclopentylmethyl methanesulfonate; Prostaglandin Intermediate; tert-Butyldimethylsilyl (TBS) Protected Prostaglandin Synthon; [1S-[1α,2α,3β(1E,3R*),4α]]-2-[[3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]phenyl]methyl]-4-[(tetrahydro-2H-pyran-2-yl)oxy]-3-[3-[(tetrahydro-2H-pyran-2-yl)oxy]-1-octenyl]cyclopentanemethanol methanesulfonate
EINECS	Contact for details

Quality Control

This high-value synthetic intermediate is produced under strict quality control protocols to ensure batch-to-batch consistency and purity for sensitive synthetic applications. Our quality assurance includes comprehensive analytical characterization using HPLC, GC, NMR, and mass spectrometry to confirm identity, stereochemical purity, and chemical purity. A detailed Certificate of Analysis (COA) is provided with each batch, documenting all critical parameters. We adhere to cGMP principles where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Diastereomeric Excess (de)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.