Description

(3R,5S)-5-[(2R)-2-[(1R,3aR,4E,7aR)-4-[(2Z)-2-[(3S,5S)-3,5-dihydroxy-2-methylidene-cyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]propyl]-3-hydroxy-3-methyl-oxolan-2-one is a high-purity, stereochemically defined synthetic intermediate of significant importance in advanced pharmaceutical synthesis. Its complex polycyclic structure with multiple chiral centers makes it a critical building block for the development of novel therapeutic agents, particularly in the fields of endocrinology and metabolic disease research. This compound is essential for R&D laboratories and production facilities focused on creating next-generation pharmaceuticals, requiring exceptional batch-to-batch consistency and reliable supply chains.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex steroid analogs and hormone receptor modulators.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new bioactive molecules.
• Process Chemistry: Serves as a pivotal intermediate in scaling up synthetic routes from laboratory to pilot and commercial production.
• Advanced Organic Synthesis: Employed in constructing intricate molecular architectures that require precise stereochemical control.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	(3R,5S)-5-[(2R)-2-[(1R,3aR,4E,7aR)-4-[(2Z)-2-[(3S,5S)-3,5-dihydroxy-2-methylidene-cyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]propyl]-3-hydroxy-3-methyl-oxolan-2-one
CAS No.	81203-50-1
Molecular Formula	C29H40O5
Molecular Weight	468.63 g/mol
Synonyms	Rosuvastatin Lactone Diol; (3R,5S)-Rosuvastatin Lactone Dihydroxy Intermediate; (3R,5S)-5-[(2R)-2-[(1R,3aR,4E,7aR)-4-[(2Z)-2-[(3S,5S)-3,5-Dihydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyloctahydro-1H-inden-1-yl]propyl]-3-hydroxy-3-methyloxolan-2-one; Rosuvastatin Advanced Lactone Intermediate; ZD4522 Lactone Diol Derivative; (3R,5S)-Lactone Diol
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict cGMP guidelines to ensure the highest levels of purity and stereochemical integrity. Every batch undergoes comprehensive analytical characterization, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic confirmation (NMR, IR, MS). A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes to support your regulatory filings and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.