Description

(6R,7S)-7α-[(4-Carboxy-1-oxobutyl)amino]-7-methoxy-8-oxo-3-[[[(E)-1-oxo-3-[4-(sulfooxy)phenyl]-2-propenyl]oxy]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid CAS NO 80458-11-3 is a complex, semi-synthetic cephalosporin derivative. This compound is of significant interest for its role as a key intermediate in the synthesis of advanced β-lactam antibiotics, offering a crucial building block for pharmaceutical research and development. It is primarily utilized by manufacturers and research institutions in the pharmaceutical and fine chemical sectors focused on novel antimicrobial agents.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of advanced-generation cephalosporin antibiotics.
• Antibiotic Research & Development: Used as a standard or building block in R&D for creating new β-lactam compounds with potentially enhanced efficacy or spectrum of activity.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses requiring a sophisticated, functionalized cephalosporin core structure.
• Reference Standard: Acts as a high-purity chemical reference standard for analytical method development and quality control in pharmaceutical manufacturing.
• Bioconjugation Studies: Its reactive functional groups make it suitable for studies involving the conjugation of antibiotic moieties to other molecules or delivery systems.

Basic Information

Product Name	(6R,7S)-7α-[(4-Carboxy-1-oxobutyl)amino]-7-methoxy-8-oxo-3-[[[(E)-1-oxo-3-[4-(sulfooxy)phenyl]-2-propenyl]oxy]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS No.	80458-11-3
Molecular Formula	C25H27N3O13S2
Molecular Weight	641.62 g/mol
Synonyms	7-Methoxy Cefotaxime Impurity; Cefotaxime 7-Methoxy Impurity; Cefotaxime Related Compound; 7α-Methoxy Cefotaxime; 7-Methoxy Cefotaxime; 7-Methoxycefotaxime; (6R,7S)-7-Methoxy-3-[(E)-2-(4-sulfonyloxyphenyl)ethen-1-yl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cefotaxime 7-Methoxy derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We offer grades suitable for research and pharmaceutical intermediate applications, with typical purity specifications exceeding 95% (by HPLC). Certificates of Analysis (COA) detailing identity, purity, and related substances are available upon request. Production can be aligned with cGMP guidelines for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.